So the theme emerging the last few days has been that people are being told that the histaminosis/histamine intolerance is all in their head. The usual. Only rather than doctors, it’s friends and family telling them.
It’s only since my recovery that people have stopped trying to convince me I’m nuts. In a way it’s understandable. I have come up with a million reasons for my illnesses over the years. Many were the fault of doctors. I collected diagnoses like dogs acquire fleas. They were just about as useful as fleas…
Please, the next time someone tries to tell you that your palpitations are just “anxiety,” first, ask yourself if you are anxious about something.
If not, next time you see your friend, quote this:
Sometimes (ruling out heart conditions) the reason people with histamine issues have palpitations after foods (used to happen to me particularly with chocolate and strawberries) is that histamine is vasoactive.
Since this post I have found that oxalic acid found in plants is quite possibly far more of an issue than histamine/mast cells in my bladder issue. Moderating oxalate combined with my histamine balanced diet has completely cleared up my life long bladder pain and frequency. Read the post here.You can buy the low oxalate cookbook here.
I’m busy compiling a doctor “wish-list” for exploring my histamine-related disorder. So far, at the very top of it is Dr. Theoharides of Tufts University in Boston. I’ve been taking his high dose quercetin supplement, Neuroprotek for just over a week now and it seems to be making a big difference in my histamine intolerance/histaminosis/mast cell activation symptoms. While perusing the swathes of research (that he has conducted) on his site – one on Interstitial Cystitis caught my attention. Having been misdiagnosed with UTI, despite negative culture, I once again wondered why none of my doctors were aware of this research.
Here’s an excerpt from a talk with doctor Theoharides. You can read the full text here.
Moderator: Jill Osborne, M.A. President & Founder Interstitial Cystitis Network, Santa Rosa, CA USA http://www.ic-network.com
REDUCING INFLAMMATION AND RESTORING BLADDER MUCUS The Role of Quercetin, Glucosamine & Chondroitin
“In either case, we believe that a central cell for the initiation of the inflammation, whether it’s from the bladder in, or the inside is the MAST CELL. Let’s give an example of what happens if there is an insult from the bladder. Let’s call it… X…. will damage the GAG layer and get to the urothelial cells. The urothelial cells are not supposed to deal with any triggers. Once they feel the trigger, they send the message on to the SUBMUCOSA, the layer right behind the urothelial cell and very rich in nerves and mast cells.
In the submucosa, mast cells will immediately be activated and will release three sets of molecules that are very important in inflammation:
1 – Histamine will make the blood vessels leaky. This will allow circulating white blood cells to come out of the vessel and into the tissue to take care of the offending molecule. This process makes the blood vessels swell up and create openings where the white blood cells can come out and enter the bladder to take care of the trigger. When you see inside the bladder with a cystoscope in many IC patients, the urologists see what are described as glomerulations, which are microhemorrhages. In other words, the dilation of the blood vessels (and through the blood vessels) both white cells and blood emerge thus creating the petechial hemorrhages that your doctor may see.
2 – Cytokines that make the wall of the blood vessels product “docking” areas (called vascular adhesion molecules) to which the circulating white blood cells attach and exit.
3 – Chemoattractants that draw circulating white blood cells to bladder tissues.”
Have you been diagnosed with IC or recurrent UTI and now suspect it could in fact be related to your histamine issues?
It’s finally here! Man Food – a high nutrient antihistamine and anti-inflammatory ingredient filled book geared towards guys, women who love to work out, yoga like they mean it, or just load up on healing nutrients. Features my personal shopping list of antihistamine and anti-inflammatory foods.
The Anti-cookbook and all liquid Anti-Detox Book, don’t treat any conditions, but feature a plethora of the high nutrient antihistamine and anti-inflammatory ingredients that have been instrumental in helping me feed myself on a limited diet. The Anti-cookbook features a six page list of antihistamine and anti-inflammatory foods and comes in regular and Paleo.
The Low Oxalate Cookbook features antihistamine and anti-inflammatory rich recipes.
Don’t miss the Low Histamine Beauty Survival Guide for non-toxic beauty tips, the skinny on histamine releasing (mast cell degranulating) beauty ingredients, antihistamine and anti-inflammatory beauty alternatives and the top brands natural brands I’ve found.
Estrogen can cause major histamine release in the body. Now why would you want that? Because histamine makes you um, randy, and your biological imperative is to procreate. We shouldn’t really complain though,estrogen makes us more attractive to the opposite sex…but back to my point.
Studies on female rats show that estrogen supplementation, or natural fluctuations in cycle near ovulation, cause libido boosting histamine release. Didn’t know that histamine affects your sex drive? You’re welcome! Please explain to your significant other that spiking your meals with cashews isn’t necessary thank you very much. It’s one of the many perks/crosses to bear with our histaminosis/histamine intolerance diagnosis.
Estrogen is important in female precopulatory behaviors in 3 m ways: 1) estrogen increases a female’s willingness to approach a male to induce solicitatious behaviors, 2) estrogen can enhance the “attractivity” of the female: estrogen priming can induce the production of stimuli that make her more attractive to the male (odors or pheromones, vocalizations), and 3) estrogen ‘primes’ for progesterone.
My very first Balinese steps assured me I had found heaven on earth. The airport’s delightfully kitsch tourism ministry infomercials and the frosted mirrors transported me back to the 70s, not in a dingy, dirty way like it does in Bangkok’s seedy after-hours bars, but in a Brady Bunch meets the original Batman series, by way of the most beautiful spa you’ve seen.
Best of all? No chemicals used by the agricultural, um, industry. I don’t know if I’d call it an industry there, but I guess that’s the point. I began every day luxuriating in a chlorine free bath, followed by coconut oatmeal with fresh mango. Dinner was invariably spicy, served on a crappy plastic table, right on the beach. I’d wander into the water with my plate, eating as I waded through the ocean. Like I said, heaven.
Here on earth, we do the best we can to recapture those celestial aromas and flavours, usually on the kitchen stove, now with the benefit of knowing the effect of diet on our physical and mental well-being. So here’s my take on my Balinese favourite, Sambal, low histamine, for all us histamine challenged folks.
Don’t forget to sign up to my newsletter for a 10% discount on my upcoming ‘On the Go’ book. Healthy low histamine meals for professionals on the go. Most are 10-15 mins prep, natural foods with few ingredients but lots of flavour!
Is pain “down there” ruining your life? You’re not alone. Chronic “lady pains” were a hot topic at the hista-sista kvetch-sesh in Notting Hill yesterday. The abundantly histamine blessed ladies and I compared notes. The term “chronic pelvic inflammation” of idiopathic origin and vulvodynia came up quite a bit, as did its disastrous effect on mental health and intimacy with our partners.
I went home and did some research. Obviously, there was a link. It’s something that almost every single woman with histamine issues (that I’ve been brave enough to ask) has complained of.
Here’s what I found:
“Our data suggest that women with a history of urticaria, seasonal allergies or reaction to insect stings appear to be more prone to later development of vulvodynia than women with no history of these allergic reactions. We also showed that this association was largely confined to exposures that occurred before the first onset of vulvar pain, suggesting that allergenic exposures could be involved as, or a marker of, factors involved in the development of vulvodynia. We also observed that a history of other skin conditions, not as strongly related to an immune response, generally were not associated with the risk of vulvodynia. [1]”
And…
“Vulvodynia is a complex disorder and described as discomfort or intense burning pain in the vulvar area. Such chronic pain affects 5 to 15% of women and many suffer of misdiagnosis. For sure the aetiology is multifactorial. Through few studies we consider the inflammatory response plays a major role. There is a genetic profile of women suffering of vulvodynia, especially genetic polymorphisms from genes coding for cytokines, Interleukin-1 receptor antagonist and Interleukin-1 beta, and gene coding for mannose-binding lectin (MBL). These polymorphisms result in a stronger inflammatory response and lay these women in a susceptibility situation. Histological analysis showed a chronic non specific inflammation. We have also demonstrated that these patients present in normal state or under infectious induction an inadequate inflammatory response. But there is still a variety of mechanisms which can interact with the inflammatory response. Management of such vulvar pain syndrome could be very frustrating, but the first step for improvement is to get the right diagnosis [2].”
What I found particularly healing was cutting down on high oxalic acid foods like curly kale and most grains. That cleared up much of my bloating, interstitial cystitis and general sense of malaise. It took a while, but was worth it. I hadn’t realised initially that oxalates were as big an issue for me as histamine. I highly recommend getting tested if you feel this is your issue. You can check out my oxalate post here.
All the more reason to look after your health/diet and be good to yourself (lady parts included). I’m off to make a very low histamine anti-inflammatory dinner – you’ll find plenty of recipes in my Man Food bookthere’s also lots of information and low oxalate recipes in my Low Oxalate Cookbook.
It’s finally here! Man Food – a high nutrient antihistamine and anti-inflammatory ingredient filled book geared towards guys, women who love to work out, yoga like they mean it, or just load up on healing nutrients. Features my personal shopping list of antihistamine and anti-inflammatory foods.
The Anti-cookbook and all liquid Anti-Detox Book, don’t treat any conditions, but feature a plethora of the high nutrient antihistamine and anti-inflammatory ingredients that have been instrumental in helping me feed myself on a limited diet. The Anti-cookbook features a six page list of antihistamine and anti-inflammatory foods and comes in regular and Paleo.
The Low Oxalate Cookbook features antihistamine and anti-inflammatory rich recipes.
Don’t miss the Low Histamine Beauty Survival Guide for non-toxic beauty tips, the skinny on histamine releasing (mast cell degranulating) beauty ingredients, antihistamine and anti-inflammatory beauty alternatives and the top brands natural brands I’ve found.
I found this particular email very interesting given that I’ve been misdiagnosed with thyroid issues twice in my life before being finally diagnosed with a histamine related disorder (high histamine/histamine intolerance/histaminosis). I refused meds the first time but gave in on the second. What a weird, crazy ride Levothyroxine sent me on. We’re talking severe mania here. Awake for days on end, racing thoughts, very productive behaviour till the crash. And boy was it spectacular!
Medicine has sent me on so many Alice in Wonderland trips that I didn’t necessarily think there was a link when I began my investigations, but a little research turned up that not only do thyroid meds (synthetic thyroxine) raise histamine levels, they also lower diamine oxidase and monoamine oxidase, the enzymes responsible for metabolising histamine and tyramine (respectively).
Circulating levels of 5-hydroxytryptamine (5HT), histamine, monoamine oxidase (MAO), histaminase, tri-iodothyronine (T3) and thyroxine (T4) were studied in L-thyroxine and carbimazole treated rats. Increased concentrations of 5-HT, histamine, glutamate, T3 and T4 were recorded in L-thyroxine-treated rats while plasma gamma-aminobutyric acid (GABA), MAO and histaminase levels were significantly decreased. The findings suggest that alterations in the metabolism of thyroid hormones may have a link with the altered metabolism of biogenic amines. Read the full study here.
And another that mentions cardiac involvement:
Thyroxine-induced supersensitivity to histamine and norepinephrine activation of cardiac phosphorylasea. The results indicate that thyroid hormone can enhance both histamine and norepinephrine-induced activation of cardiac phosphorylasea. Possible mechanisms of this interaction are discussed. Read the full study here.
Thyroxin induced supersensitivity. Yes, that’s one way of referring to the hell that I went through on these meds. The next endocrinologist I consulted with called it “a sub clinical diagnosis” that should never have been tampered with. He did not in any way attribute my anxiety/mania symptoms to it. I asked. Sheesh. I’ve seen a lot of silly docs over the years. This might be something to keep in mind if you’ve been diagnosed with a histamine related disorder.
Please consult your doc before even thinking about messing with your meds!
This week I had the pleasure of meeting Barcelona-based nutritionist Adriana Duelo. She has kindly allowed me to re-blog an article that was originally part of her nutritional thesis. Adriana’s research is regularly submitted to the prestigious SPANISH SOCIETY OF DAO DEFICIENCY (of which she is also a member). Something that quickly caught my eye on Adriana’s website was a breakdown of histamine content in some popular foods. The charts and the text below were translated from the spanish on her site (using Google Translate). Adriana herself speaks perfect English and will be sharing a few more interesting articles for release through my site in the coming weeks.
Histamine levels in popular foods
Were you as surprised as I by some of these results? I was excited to see chocolate scoring so low – but we already know that cacao is more of a histamine liberator rather than being high in it. Alcohol, though not too high histamine, has the very unfortunate effect of blocking DAO (diamine oxidase) production. I don’t feel that bad when I drink (as long as I stick to tequila, rum or gin), but feel horrible for days afterwards when things I usually tolerate suddenly start bothering me.
Histamine levels in popular foods
Milk certainly shocked me, though it’s not relevant to me as I don’t indulge in dairy. My home made (raw) chocolate bars are pure cacao and almond butter. Before you rush out and indulge in all the things you’ve thought were off the menu – please read the text below from Adriana’s site where she points out that not only is there some dispute about the histamine content of foods, but also at what concentration (mg per kilo) to avoid them.
Histamine levels in popular foods
I personally don’t think people should be too strict. I’m only as strict as I have to be and most of the time chemicals bother me more than foods. I understand that histamine is necessary for almost all bodily functions, but that doesn’t give me permission to pig out on pizza and sausage. I’m much more likely to be found adding tomatoes to my salads and pineapple to a smoothie.
Histamine levels in popular foods
Continued from Adriana Duelo’s site….
FOODS RICH IN HISTAMINE
The lack of enzymatic activity of Diamino oxidase (DAO) can cause different symptoms in our body that is manifested by several signs, as shown in an article published last month in this blog: ” Deficit of enzyme DAO . “
First, is diagnosed when there is a lack of DAO activity with a blood test, the nutritionist can rate portal as a diet low in histamine and other amines . (These other amines also be taken into account, but I’ll leave for another article).
This pattern is essential to prevent the onset of symptoms (one of the main, the migraine ), so you need to degrade histamine enzyme DAO, and but we have enough accumulated histamine can produce symptoms mentioned.
From this diet, while nutritionist decide if, moreover, the supplies necessary for a DAO enzyme dietary supplement to help absorb the low histamine foods that we ingest.
There is disagreement over the criteria to be followed for the consideration of whether or not a food rich in histamine. Some authors suggest avoiding those foods from the diet that have concentrations above 20 mg / kg, while others are much more demanding and consider foods with low amounts of histamine which contain less than 1 mg / kg. ‘ What is clear is that the dose symptomatological is much lower in patients with CAD deficit in sporadic histamine poisoning: 15-20mg and 150mg respectively. This demonstrates clearly important in a diet low in rate portal histamine deficit in patients with CAD.
My typical weekday breakfast is half a mango wolfed down on my way to the tube, so I usually go for broke on the weekends. Yesterday, however, the sun was out and we decided our top priority was to get out and enjoy it. I whipped up a batch of the DAO Support Book Breakfast Bars (recipe available in the DAO Support Recipe Book for sale in my online store) but added generous globs of homemade sugar-free blueberry jam in addition to the berries. They came out deliciously gooey!
Here’s the low histamine, sugar-free blueberry jam recipe that I added to the recipe book energy bars.
Low Histamine Blueberry Jam
Sugar free low histamine jam for DAO Support Breakfast Bars
1 cup blueberries
1 apple, grated
1/2 cup apple juice, fresh
1 tbsp lemon juice
Prep:
Place the washed blueberries and grate apple in a pot. Cover with apple juice and bring to a boil while stirring. Turn down to a simmer – liquid will thicken in about 5 mins. You can add some agar agar, about 1-2 tbsp depending on desired thickness. [shopeat_button]
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