New studies show that aerobic exercise raises histamine levels. This isn’t news to me. When playing squash I have to take time outs to scratch myself silly and wait for the room to stop spinning. My man, now used to such bizarre-isms, plays against the wall for a while till it calms down again. I looked a lot crazier, to a much larger crowd, during our recent trapezing class! I’m sure I can thank adrenaline for that…What really interested me in this particular study is that they determined resistance training (weights/yoga) doesn’t raise histamine levels. They highlight how histamine released by aerobic exercise causes significant vasodilation (the widening of blood vessels in the body).This study ties in nicely with last week’s post about histamine being a vasoactive amine that can increase or decrease heart rate and induce anxiety-mimicking symptoms.
*Resistance training is any exercise that causes the muscles to contract against an external resistance with the expectation of increases in strength, tone, mass, and/or endurance. The external resistance can be dumbbells, rubber exercise tubing, your own body weight, bricks, bottles of water, or any other object that causes the muscles to contract. http://www.emedicinehealth.com/strength_training/article_em.htm
Interestingly, I meeting quite a few people who are being prescribed anti-histamines by their docs to deal with asthma/wheezing, abnormally high heart rate and passing out while exercising. Wouldn’t it be simpler to go on a low histamine diet? Probably not, but it would yield better (healthier) results!
What does this mean for your work out routine?
Aerobic exercise, like my current favorites kickboxing and squash, can significantly raise histamine levels in the body. The upside (because in my world there always is one) is that people pay good money for pharmaceutical vasodilators to lower their blood pressure. The downside (other than the spike in histamine for those of us with histaminosis/histamine intolerance), is the migraines that accompany vasodilation. I often get migraine like headaches if it’s too hot in yoga class.
Does this mean I shouldn’t exercise?
I’m asked this a lot, usually by life long couch potatoes!
What I take from this study is that it might be a good idea, if you’re suffering from histaminosis/histamine intolerance, to explore “non dynamic” exercise like weight training, or my perennial favourite, yoga. Speaking of which, did you know that one of the many studies on yoga showed that females who practiced yoga regularly had 41% lower stress markers than non-yogis? And significantly lower inflammation! Given that inflammation (caused by high histamine) is a huge concern to those of us with histaminosis/histamine intolerance, it’s food for thought the next time you’re crashed out on the sofa telling yourself that exercise is bad (while contemplating another root around the fridge).
So what’s a histamine-challenged gal to do?
We’ve all been there, but there’s really no time like the present for a full body/mind make over. Try waking up tomorrow and investing in a yoga mat and a $15 subscription to Yogaglo online classes. I promise you won’t regret it.
Don’t forget to sign up to my newsletter for free recipes and a 10% discount on ebooks…and why not check out how I keep my histamine level in check and stay anti-histamine free with my low histamine DAO Support Recipe Book and The Low Histamine Desserts Book?
Make-up allergies got you down? Have you considered that your beloved cosmetics are causing your histamine intolerance/chemical sensitivity/mastocytosis to flare up? If you’re on a low histamine diet but still suffering from make-up allergies, rashes and migraines, don’t despair, just bin the histamine raising dirty cosmetics! I did…
As the head of a successful digital agency in London, meeting and pitching clients is a daily requirement, and looking good is a must. It took me a long time to accept that cosmetics played a role in my declining health. But once I did, I worked hard to get out of the toxic mindset and figure out alternatives. In this ebook you’ll find the tips, tricks and coping strategies I’ve discovered, developed and employed these last two years, that helped me stand out from the crowd in one of the world’s most fashionable cities.
This book lists my favourite non-allergenic make-up, beauty, cleansing and styling products, home-made beauty product recipes and my personal beauty & make-up routine, as well as featuring a number of natural cosmetic video make-over tutorials and tips on everything from the perfect updo to how to have “the talk” with your hairdresser. You’ll find pages of resources and information on the biggest scams the make-up industry has perpetrated: hypoallergenic make up, organic labeling, carcinogenic ingredients and the hypocrisy of the pink ribbon campaigns.
Please sign up to the mailing list for a 10% discount on this and other books.
I find it a little bizarre that not many out there are talking about the impact of cosmetics. Even when following a low histamine and tyramine diet to the letter (almost impossible but can be done for short periods) I still suffered symptom flare ups. My attitude at the time was: “hey, I’m suffering so I may as well pig out”. Wrong. Oh so very wrong.
Then I read this great book ‘No More Dirty Looks’. It got me thinking. If 60% of what we put onto our bodies is absorbed into our bloodstream (I still can’t find the science behind this claim),then why aren’t I concerned about what it could be doing to my histamine, tyramine or other amine levels?
FEB 2016 UPDATE: More importantly, research soon revealed that chemicals and additives commonly found in most cosmetics and bath products (even the supposedly natural/organic ones) have been shown to trigger histamine release, mast cell activation and cause other immune and endocrine dysfunction. Thankfully I’m now ok with most truly organic and raw beauty products (like the RMS beauty product pictured above), as long as they’re not heavily perfumed.
Here’s a few steps to detox your beauty routine…there’s a video where I share my favourite products in a little beauty make over.
FEB 2016 UPDATE: I’ve started dipping my toothbrush in non corn xylitol which is wonderful at preventing tooth decay.
5. Embrace natural brands.
Rose Marie Swift (RMS Beauty) is my hero! A trailblazing make up artist to the world’s supermodels (including Giselle Bundchen) who sufferers from chemical sensitivity. Her make up has 4-6 ingredients, mostly raw organic. They double up as moisturiser and make up. Does not raise my histamine or drive my immune system into a frenzy. I do have to stick to the light/nude colours which I love anyway. Reds (carmine) make my lips and eyes swell horribly. I also love my latest discovery Mineral Fusion for eyeliner and Hemp Organics for lipstick. You can find both of those brands at any Whole Foods in the States but not in the UK.
Dr. Oz calls inflammation an “invisible civil war raging in your body. Undetected it can cause heart attacks, stroke and cancer.” According to him, the problem begins when inflammation does not resolve following its role in healing an injury, causing your immune system to go haywire, turning your best friend into your worst enemy. This ties in to all my reading of this last year. Yes, inflammation is a serious concern when it unnecessarily stokes the immune system into over reacting to everything. Inflammation isn’t just dangerous to those of us with inflammation-induding histamine related disorders like histamine intolerance, histaminosis, mastocytosis and mast cell activation, it’s relevant to anyone with an interest in minimising their cancer, stroke and heart attack risk.
PRE-ECLAMPSIA – excessive maternal inflammatory response to pregnancy…(here’s a study on histamine in pregnancy)
And that’s where the low histamine diet comes in, at least for me. Histamine causes inflammation. Controlling its intake, especially when already dealing with a histamine-related issue, is a good first step, as is adding more anti-inflammatory foods to the diet. A word of caution here: just because something is anti-inflammatory doesn’t mean that you might not have a histamine reaction to it. We’re talking a straight up classic histamine/IgE mediate allergy or food intolerance here.
So, now you’re aware of why you need to be fighting inflammation, but what’s the best way to do it? I take a three pronged approach: diet (check out my low histamine cookbooks for recipes), supplements and lifestyle.
Vitamin K status, as measured by plasma phylloquinone and phylloquinone intake, was significantly inversely associated with the overall inflammation index, which represented the sum of the normalized deviates of the individual markers. Secondary analyses of the individual markers demonstrated significant (p<0.01) associations with 5 of the 14 markers. A two-fold higher plasma phylloquinone concentration was associated with 15 percent lower CD40 ligand, three percent lower intracellular adhesion molecule-1, eight percent lower interleukin-6, four percent lower serum osteoprotegerin, and four percent lower tumor necrosis factor receptor-2 concentrations in multivariable-adjusted analyses. Usual dietary phylloquinone intake was also significantly (p=0.01) inversely associated with C-reactive protein, fibrinogen, interleukin-6, lipoprotein phospholipase A2 mass, myeloperoxidase, osteoprotegerin, and urinary isoprostanes.
Histamine release inhibitors in watercress (Nasturtium officinale) were isolated using a monitoring system with antigen-stimulated RBL-2H3 cells. Of the 15 compounds isolated, flavonols and megastigmanes significantly inhibited histamine release. Two flavonols, 3-O-sophorosides of rhamnetin and rhamnazin, were new compounds. To investigate the inhibitory mechanism, the effects of rhamnetin, rhamnetin 3-O-sophoroside and an isolated megastigmane glucoside on the increase in the intracellular free calcium concentration were examined at a concentration providing 60% inhibition of histamine release. The results suggest that these compounds did not affect the calcium influx at that concentration. The structure-activity relationships of the megastigmanes on histamine release were also investigated.
We examined the effect of a crude hot-water extract (HW) of quince (Cydonia oblonga Miller) fruit on type I allergy in vivo and in vitro. The oral administration of the quince HW-added diet to NC/Nga mice for 63 d showed a significant decrease in the development of atopic dermatitis-like skin lesions under conventional conditions. The concentration of IgE in the serum collected from mice fed with quince HW was also lowered in a dose-dependent manner. Moreover, we found that quince HW inhibited the release of beta-hexosaminidase from rat basophilic leukemia cell line RBL-2H3 after a 24-h treatment. The quince HW fraction of less than 3 kDa reduced the mRNA expression of the high-affinity IgE receptor (FcepsilonRI) gamma subunit. These results suggest that quince HW had an inhibitory effect on type I allergy by suppressing IgE production and IgE-mediated degranulation.
The human body is made of some 250 different cell types. From them, only a small subset of cell types is able to produce histamine. They include some neurons, enterochromaffin-like cells, gastrin-containing cells, mast cells, basophils, and monocytes/macrophages, among others. In spite of the reduced number of these histamine-producing cell types, they are involved in very different physiological processes. Their deregulation is related with many highly prevalent, as well as emergent and rare diseases, mainly those described as inflammation-dependent pathologies, including mastocytosis, basophilic leukemia, gastric ulcer, Crohn disease, and other inflammatory bowel diseases. Furthermore, oncogenic transformation switches some non-histamine-producing cells to a histamine producing phenotype. This is the case of melanoma, small cell lung carcinoma, and several types of neuroendocrine tumors. The bioactive compound epigallocatechin-3-gallate (EGCG), a major component of green tea, has been shown to target histamine-producing cells producing great alterations in their behavior, with relevant effects on their proliferative potential, as well as their adhesion, migration, and invasion potentials. In fact, EGCG has been shown to have potent anti-inflammatory, anti-tumoral, and anti-angiogenic effects and to be a potent inhibitor of the histamine-producing enzyme, histidine decarboxylase. Herein, we review the many specific effects of EGCG on concrete molecular targets of histamine-producing cells and discuss the relevance of these data to support the potential therapeutic interest of this compound to treat inflammation-dependent diseases.
Ethanolic extract of fruits of Coriandrum sativum, leaves of Datura stramonium and Azadirachta indica showed a significant (p<0.01) inhibition of carrageenan induced rat paw edema and the results are presented in table -2. The extract of C. sativum, D. stramonium and A. indica showed 40.81%, 39.43% and 46.47% edema inhibition respectively after third hour at 200 mg/kg dose. Maximum activity was found at 3.0 hr intervals with each dose. Among these plant Azadirachta indica showed maximum anti-inflammatory activity every hour. The inflammation induced by carrageenan is biphasic in nature. The initial phase of edema has been attributed to the release of histamine and serotonin; the edema maintaining during the plateaue phase, attribute to kinin like substances and the second accelerating phase of swelling is attributed to the release of prostaglandin [12, 13]. Since the extract of C. sativum, D. stramonium and A. indica inhibited the carrageenan induced edema that involves release of histamine and serotonin in the first phase; hence the inhibitory effect of the extracts could be partly due to inhibition of mast cell mediator release.
Dr. Theoharides’ Neuroprotek quercetin supplement is not only the cleanest, but also the most effective that I have come across in years. I will soon be selling it through my site, in the meantime please visit my good friend’s website to order.
I’m usually on the fence about homeopathic remedies. I’d love to believe they work, but have yet to see the studies backing up their claims. Today however I found a study showing that a homeopathic remedy, Rhus Toxicodendron, “significantly reduces” carrageenan induced inflammation in rats. As I mentioned in another post, carrageenan (irish moss) is a seaweed derived food additive that is also frequently used in raw food desserts . 2016 update: sorry I should say that irish moss is used in raw foods, not carrageenan. Carrageenan is however found in many organic and natural foods as well as toothpaste.
The study authors note: “We found significant reductions compared to control in carrageenan-induced paw oedema, vascular permeability, writhing induced by intraperitoneal acetic acid and stress induced gastric lesions. Rhus tox in homeopathic dilution appears to interfere with inflammatory processes involving histamine, prostaglandins and other inflammatory mediators.” But that doesn’t mean upping the dose will get you more inflammation relief, on the contrary…”Administration of a single dose of Rhus tox 1h prior to injection of Carrageenan significantly reduced the paw inflammation in a dose dependent manner. Administration of multiple doses of Rhus tox increased the intensity of inflammation induced by Carrageenan, but this was not statistically significant. [1]
Ok here’s one I totally relate to. Dr. Mehmet Oz, on his show, recently explained how hidden food allergies can make you gain up to 30lbs (20kg) a YEAR.
food allergies make you fat!
Here’s Dr. Oz on his show explaining how, when faced with an undiagnosed allergy whereby the good bacteria cannot process the food (I think maybe he’s referring to the histamine degrading enzymes diamine oxidase, monoamine oxdase and HNMT) the body responds with inflammation that quickly distends the bowels, stomach and surrounding areas, adding up to 30 pounds (20 kilos) of weight EVERY YEAR.
“Gulp”. Yes, I have experienced that first hand. I finally lost 35 kilos (77 lbs) over two years ago, as a result of going on a low histamine diet. I lost the equivalent of a small person!
I attribute some of the weight loss to stopping the anti-histamines which were making me eat like a football player. A football player who has been wandering the dessert without food for two weeks, with only a bag of ganja to sustain him. Yeah, I was obsessed with food, allergenic food that was causing inflammation thanks to a lack of histamine-degrading diamine oxidase, monoamine oxidase and others. But even before then, my friends were always as baffled as I by my weight gain. Was I eating in secret? Was I sleep eating? These were valid questions but I wasn’t.
I can’t say I haven’t become healthier overall since going low histamine, because I definitely have, but my calories aren’t that much lower now. I even eat more dessert now than I used to, which brings me back to how to pig out without gaining weight. Can you guess?? Yup, my first dessert book is finally out! The Low Histamine Dessert Book is gluten-free, milk-free and refined sugar free. All low histamine desserts have been tested out on my non-amine challenged friends…this is the good stuff that I break out for tea, after dinner treats and kiddie birthday parties! The moist chocolate (make it with carob or cacao, there are instructions for both) is perfect for birthdays, and no one has no come back for seconds of the delicious almond butter cupcakes. Though you can frost them with anything…
You can download the low histamine dessert book here. If you’re dealing with histamine-induced weight gain from anti-histamines, histamine intolerance, histaminosis or mastocytosis, you might want to check out my Low Histamine Diamine Oxidase Support Cookbook first!
Diagnosed with histamine intolerance/histaminosis, mast cell activation or mastocytosis? Looking for a tasty treat but have no clue where to start? My first dessert book – the Low Histamine Dessert book – is gluten free, milk free, and refined sugar free, perfect for those necessary indulgences, without the histamine hangover.
I’ve always been a healthy dessert person, mainly because sugar just makes my stomach turn inside out.
The Low Histamine Dessert Book features a number of pages of substitutions but please feel free to contact me through the forum, or by email, if you have any questions.
And don’t worry…this book does feature my anti-inflammatory donut recipe! You can download the Low Histamine Dessert Book here.
Middle Eastern & Indian spices lower histamine in foods!
More reasons to go natural – here’s a study showing that the addition of Middle Eastern spice sumac to Turkish sausage lowers the biogenic amines tyramine and putrsecine in foods more effectively than BHT (butylated hydroxytoluene).
Unfortunately Sumac did not show the same effect on histamine.
For that we have to travel half way across the world to Sri Lanka and India where people have been using Garcinia Cambogia (mangosteen family) leaves to prevent histamine contamination in fish for centuries. Whether or not they actually knew that’s why they were doing it is another story.
Histamine consumed with food gives rise to allergic reactions. Dark muscle fish, for example skipjack (Katsuwonus pelamis) has been shown to contain histamine. Addition of the spice Garcinia cambogia (extracts 0.2 g ml-1) known as ‘goraka’ in Sri Lanka (sinhala) and ‘kukum’ in India (hindhi), to fresh skipjack incubates prevents histamine formation as a result of lowering pH to 3.2-3.6.Read the full study here.
This naturally makes me wonder if Garcinia Cambogia has the same effect in the human body, at least for those of us with histamine related disorders (histaminosis/histamine intolerance/mastocytosis). Anecdotal evidence put forward by natural supplement pushers would have us believe it does. Garcinia is currently touted as a cure all for allergies, food intolerances, and hay fever. I’ll wait for the solid research to back it. Or at least till the box of garcinia tea I ordered arrives. Your intrepid reporter will keep you posted on her results.
In the meantime, I’d love to know why we in the west haven’t adopted this natural herb for the prevention of unacceptable histamine levels in fish. After all, it’s not just those of us with histamine intolerance, histaminosis, mastocytosis and mast cell activation disorders who are adversely affected by high histamine levels in foods. Government bodies now freely admit histamine in foods is a growing concern to “healthy” people, not just those of us with histamine disorders.
