Leaky gut: the mast cell (histamine), Crohn’s disease connection

leaky gut mast cells histamine


You know how people with mast cell issues have, erm, less than stellar memories? Well, I came across a piece of research last year that confirmed something I already believed, but had no proof to back up; and then promptly forgot to share it with all you lovely people.

In my defence, I spend several hours a day reading research, and what doesn’t surprise me generally doesn’t make it to print (so to speak).

So, for those of you who have been living on another planet for the last few years (or are new to the whole “google is my doctor” cult), leaky gut, or intestinal permeability as it’s referred to by people who worry calling something “leaky” will delegitimise it in the eyes of the scientific community, is a nasty piece of work. It’s basically an inflammation induced breach of the intestinal barrier that’s meant to keep food particles out of the blood stream.

Signs you have a leaky gut [1]

Digestive issues (gas, bloating/IBS)

Seasonal allergies/asthma

Diagnosis of autoimmune disease: RA, Hashimotos’s, lupus, psoriasis, celiac

Mood disturbances: depression, anxiety, ADD/ADHD

Skin issues; acne, rosacea, eczema

Food allergies/intolerances

Hmmmm, where else have I seen all of these symptoms on one list?

Oh wait, histamine/mast cell disorders!

CLICK HERE FOR A FOUR WEEK HISTAMINE RESET WITH MEAL PLANNERS, STRESS RELIEF STRATEGIES & MORE

Cartoon Basketball with Stop Sign

Since finding (and forgetting about) the research, a couple of great posts have been written on it. In particular, Chris Kresser, Dr Mark Hyman and others are all talking about quercetin as a highly effective treatment for leaky gut [2,3]. This would be, because as studies now show, intestinal permeability is caused by increased mast cell activity in the gut [4].

Dr Hyman goes so far as to say: “We also use herbs like quercetin and turmeric to reduce inflammation and heal a leaky gut.”

You’ll find recipes full of foods with antihistamine and anti-inflammatory properties my books Anti-Recipes and The Anti-Cookbook

Note: some people with the COMT or MAO genetic mutations may react negatively to quercetin and turmeric [5]. I myself have both mutations and reacted to both of them initially, but am now fine with them. The beauty of epigenetics…I truly believe we can influence the genetic blueprint we’re born with, it’s the cornerstone of my dietary philosophy.  

And get this, people write to me all the time asking if Crohn’s is related to mast cells. Well, I’ve seen some studies…but interestingly, as far back as the 80s, researchers at UCLA proposed that “increased intestinal permeability could contribute to the cascade of events that culminate in active Crohn’s disease.” [6].

Oh my.

I suffered from insanely horrific intestinal issues for most of my life. Basketball stomach doesn’t even begin to cover it. My poor (not so) little tummy has been busting at the seams for most of my life. Though I wasn’t a chubby kid, my stomach really announced itself. My big brother enforced sit ups from a young age; nothing doing. That stomach just wouldn’t deflate. How could it though? My intestinal woes swung from constipation to its counterpoint at the drop of a hat.

Bloating?

Man, you haven’t experienced severe bloating till your mom’s had to carry you screaming from a concert (no mean feat given that I was 11 at this point) and then use scissors to cut your jeans waistband, now so embedded into triple basketball stomach that it has disappeared into it, in order for you to breathe again.

CLICK HERE TO LEARN EXACTLY HOW I HEALED MY GUT AND HOW TO CREATE YOUR OWN HISTAMINE BALANCED DIET. 

Given that I’m no longer worried about embarrassing the hell out of a boyfriend by sharing even more than I usually do, I’ve decided, that as it’s #throwbacktuesday or thursday or whatever (oops I missed my post date – this’ll have to do), I’ll share with you a photo taken the last time I went off diet. It’s a funny story see, doctors wouldn’t believe me, saying that if I managed to control my symptoms through diet, then I obviously didn’t have a mast cell disorder…

I’ve decided that most doctors are inherently illogical beings when it comes to diet.

photo

 My basketball tummy, taken against a black background. Quintuplets maybe? 

And then one day, I noticed that my stomach wasn’t going all alien on me. Then there was another day, and another, and suddenly the norm was a flat stomach. 

Thing is, I never set out to heal leaky gut.

Because by that point, I had decided to focus on the now. To let go of the reigns, to stop second guessing myself, to give myself a little space to be, to heal, to live life. L-glutamine, bone broth, nasty ass bovine collagen oatmeal – all kicked to the curb.

photo

I’m not holding it in I promise! What my stomach now looks like 99.9% of the time – photo taken summer 2014 (I think!). 

A high nutrient, histamine-balanced quercetin, luteolin and rutin diet, quercetin supplement, positivity and meditation all came together joyously (with a little whittling down of the very high oxalate foods) to give me, while certainly not a washboard stomach, sadly being “pregnant” or “with basketball” since the age of five has taken its toll on my stomach muscles and skin tone, it’s still freaking awesome.

Something else I have noticed is that working out the stomach (something I have avoided like the plague for most of my life for some reason) keeps any hints of bloating in check. I wonder if it has something to do with localised anti-inflammatory activity from the exercise. I have found yoga particularly effective. While yoga does not traditionally work the tummy, the rocket yoga I do (ashtanga yoga’s fun bits all rolled into one and a lot faster) puts an emphasis on building the core so that we can gain strength and balance for our inversions. Here’s me below in August 2015 (I was feeling ropey but still doing the yoga) after a rocket session.

me standing in front of a mirror to show my belly

You better believe that I give thanks to the universe, my dietary philosophy, the years of research and faith I finally put in my being the best judge of what will heal me, krishna, the almighty, you name it, I’ll kiss its feet, for my finally not having to plan my wardrobe, social and sex life around the inflated tyrant that ruled much of my life.

Yes stomach, there’s no better way to put it, you’re now my b*%&@!

Now, you better believe I’m getting back to my sit ups and quercetin rich juicies (more on that in the Anti-Detox and Anti-Cookbooks)

photo

You’ll find recipes full of foods with antihistamine and anti-inflammatory properties my books Anti-Recipes and The Anti-Cookbook

———–REFERENCES———-

[1] http://www.mindbodygreen.com/0-10908/9-signs-you-have-a-leaky-gut.html

[2,3]

http://drhyman.com/blog/2013/09/17/cure-irritable-bowel-syndrome-days/

Can Quercetin Help Heal a Leaky Gut?

[4] http://jem.rupress.org/content/205/4/897.long

[5] http://drbradstreet.org/2011/03/08/dual-role-of-quercitin-as-antidepressant-and-antioxidant-a-double-edged-sword/

[6] http://link.springer.com/article/10.1007%2Fs10620-013-2721-y

94 responses to “Leaky gut: the mast cell (histamine), Crohn’s disease connection”

  1. Eiman Avatar
    Eiman

    Awesome post! I’ve been listening to the speakers in the detox summit and it’s all so much more interconnected than we thought, isn’t it? Just also want to say thanks for being so instrumental to my keeping hope alive back in October when I had 3 episodes of cardiac anaphylaxis and no one knew what was going on. Doing much better now with pure diet and stress management. Most days. 🙂 love and light to you too!

  2. Eiman Avatar
    Eiman

    Awesome post! I’ve been listening to the speakers in the detox summit and it’s all so much more interconnected than we thought, isn’t it? Just also want to say thanks for being so instrumental to my keeping hope alive back in October when I had 3 episodes of cardiac anaphylaxis and no one knew what was going on. Doing much better now with pure diet and stress management. Most days. 🙂 love and light to you too!

  3. Crohns Girl Avatar
    Crohns Girl

    Fantastic Post – thank you!

    I relate to this so well – basketball stomach! Oh yes! When I go to bed, I often feel like my tummy is a whole separate entity sleeping next to me, and the noise it makes!
    I have every jean size from 8 to 16 as I have no idea what size I’ll be next.

  4. Crohns Girl Avatar
    Crohns Girl

    Fantastic Post – thank you!

    I relate to this so well – basketball stomach! Oh yes! When I go to bed, I often feel like my tummy is a whole separate entity sleeping next to me, and the noise it makes!
    I have every jean size from 8 to 16 as I have no idea what size I’ll be next.

  5. LeeAnn Avatar
    LeeAnn

    This lines up with everything I have been researching too….just diagnosed with leaky gut,
    histamine intolerance and definitely having mast cell issues! What do you mean when you say you couldn’t tolerate quercetin and turmeric initially? I also have the MAO mutation along with 9 others and I have found that I am having a hard time with supplements right now. I use to take over 20 a day with no problem:-) Did you just push through and keep taking or did you let you body heal a little first and then retry? I am just reacting negatively to everything at this point so I try for a day or two and then stop. I so wish I would have learned all of this 10 years ago and been much kinder to my body!

  6. LeeAnn Avatar
    LeeAnn

    This lines up with everything I have been researching too….just diagnosed with leaky gut,
    histamine intolerance and definitely having mast cell issues! What do you mean when you say you couldn’t tolerate quercetin and turmeric initially? I also have the MAO mutation along with 9 others and I have found that I am having a hard time with supplements right now. I use to take over 20 a day with no problem:-) Did you just push through and keep taking or did you let you body heal a little first and then retry? I am just reacting negatively to everything at this point so I try for a day or two and then stop. I so wish I would have learned all of this 10 years ago and been much kinder to my body!

  7. Gina Avatar
    Gina

    Hi, I’m interested in your cookbook, but my son suffers from numerous life threatening food allergies. We are a peanut, tree nut, egg & mustard free home. Can you tell me if the book utilizes these ingredients in a lot of the recipes?

    Thanks!

  8. Gina Avatar
    Gina

    Hi, I’m interested in your cookbook, but my son suffers from numerous life threatening food allergies. We are a peanut, tree nut, egg & mustard free home. Can you tell me if the book utilizes these ingredients in a lot of the recipes?

    Thanks!

  9. MI Avatar
    MI

    definitely can relate to this! so you’re saying that following “A high nutrient, histamine-balanced quercetin, luteolin and rutin diet, quercetin supplement” diet that you provide in your recipe books should reduce the bloating?? Any advice on how to ease the bloating and pain that comes along with it is GREATLY appreciated. Thanks!

  10. MI Avatar
    MI

    definitely can relate to this! so you’re saying that following “A high nutrient, histamine-balanced quercetin, luteolin and rutin diet, quercetin supplement” diet that you provide in your recipe books should reduce the bloating?? Any advice on how to ease the bloating and pain that comes along with it is GREATLY appreciated. Thanks!

  11. Cara Ziegel Avatar
    Cara Ziegel

    I’d love to hear more about people getting over issues with turmeric. During my elimination diet, I discovered that I have a very bad reaction to turmeric – if I have turmeric at dinner, the next morning I’ll have massive rapid emptying and then I am doubled over with painful cramps for another 24 hours . . .

  12. Cara Ziegel Avatar
    Cara Ziegel

    I’d love to hear more about people getting over issues with turmeric. During my elimination diet, I discovered that I have a very bad reaction to turmeric – if I have turmeric at dinner, the next morning I’ll have massive rapid emptying and then I am doubled over with painful cramps for another 24 hours . . .

  13. Gerald Avatar
    Gerald

    Me, too, basketball stomach from childhood till taking up the SCD and GAPS diets March 2009 – present. Low histamine has been the most recent addition – and a very important piece of the puzzle – on my healing dietary journey, thanks to you!

  14. Gerald Avatar
    Gerald

    Me, too, basketball stomach from childhood till taking up the SCD and GAPS diets March 2009 – present. Low histamine has been the most recent addition – and a very important piece of the puzzle – on my healing dietary journey, thanks to you!

  15. Brett Avatar
    Brett

    Great post. I, too, have been suffering with what I believe to be a mast cell disorder that yields not only bloating, but voluminous and painful hives on an almost daily basis. I have been toying with the idea of trying quercetin, but I’ve read some articles that say that it remains unknown if it is safe to take quercetin for more than 2 weeks. While 2 weeks of even moderate relief would be greatly welcome, I’m hesitant to start something that cannot be taken long term, especially if it works. It would be mental torture to find something that actually gives relief, but can’t be taken every day long term. Have you seen anything indicating it is safe to take it long term? How long have you been using it? And, is there a specific dosage or brand you recommend? Sorry for the 50 million questions, but I’d greatly appreciate your input. Thank you!!

  16. Brett Avatar
    Brett

    Great post. I, too, have been suffering with what I believe to be a mast cell disorder that yields not only bloating, but voluminous and painful hives on an almost daily basis. I have been toying with the idea of trying quercetin, but I’ve read some articles that say that it remains unknown if it is safe to take quercetin for more than 2 weeks. While 2 weeks of even moderate relief would be greatly welcome, I’m hesitant to start something that cannot be taken long term, especially if it works. It would be mental torture to find something that actually gives relief, but can’t be taken every day long term. Have you seen anything indicating it is safe to take it long term? How long have you been using it? And, is there a specific dosage or brand you recommend? Sorry for the 50 million questions, but I’d greatly appreciate your input. Thank you!!

  17. Sarah Avatar
    Sarah

    Thanks for the post! I found that my gassy tummy and stomach pain went away without trying to heal right after I started following you, without trying as well! So thank you for sharing your journey with us all, you do so much good!

  18. thelowhistaminechef Avatar

    Thanks so much Eiman! I’m so happy to hear you’re doing better. Cardiac ana, wow, that’s hardcore. Amazing the difference two seemingly simple things can make. Thanks so much for your message xo

  19. thelowhistaminechef Avatar

    Thanks so much Eiman! I’m so happy to hear you’re doing better. Cardiac ana, wow, that’s hardcore. Amazing the difference two seemingly simple things can make. Thanks so much for your message xo

  20. thelowhistaminechef Avatar

    Ouch! Oh my goodness yes! The noises…hard to sleep with all that rumbling. And thank you for reading. Hoping you get some relief soon.

  21. thelowhistaminechef Avatar

    Ouch! Oh my goodness yes! The noises…hard to sleep with all that rumbling. And thank you for reading. Hoping you get some relief soon.

  22. thelowhistaminechef Avatar

    Hi LeeAnn, I just had really bad reactions to both. Quercetin made me horribly dizzy, speedy and gave me headaches. Turmeric made me itchy, bloated and gave me a really buzzy feeling. I discovered that fresh turmeric root worked much better for me (though I’m now also fine with powdered) and I mixed the quercetin with nigella seed oil and that took care of that reaction, Nigella is an H1 and H2 blocker. I ate and took both in small increments and just stuck it out, convincing myself they were good for me. It’s been my strategy this last year with pretty much everything, but my body had already done a lot of healing by then. I don’t advise doing the same, I’m not a doctor and I don’t want anyone hurting themselves!

  23. thelowhistaminechef Avatar

    Hi LeeAnn, I just had really bad reactions to both. Quercetin made me horribly dizzy, speedy and gave me headaches. Turmeric made me itchy, bloated and gave me a really buzzy feeling. I discovered that fresh turmeric root worked much better for me (though I’m now also fine with powdered) and I mixed the quercetin with nigella seed oil and that took care of that reaction, Nigella is an H1 and H2 blocker. I ate and took both in small increments and just stuck it out, convincing myself they were good for me. It’s been my strategy this last year with pretty much everything, but my body had already done a lot of healing by then. I don’t advise doing the same, I’m not a doctor and I don’t want anyone hurting themselves!

  24. thelowhistaminechef Avatar

    Hi Gina, none of these are in the anti-detox book!

  25. thelowhistaminechef Avatar

    Hi Gina, none of these are in the anti-detox book!

  26. thelowhistaminechef Avatar

    Hiya, I can’t make any claims regarding the recipes in my books. All I can say is that they are high in bioflavonoids and foods that have been shown to possess antihistamine and anti-inflammatory activity in studies. They’re the recipes that I make for myself and I have been on this diet for a while now 🙂

  27. thelowhistaminechef Avatar

    Hiya, I can’t make any claims regarding the recipes in my books. All I can say is that they are high in bioflavonoids and foods that have been shown to possess antihistamine and anti-inflammatory activity in studies. They’re the recipes that I make for myself and I have been on this diet for a while now 🙂

  28. thelowhistaminechef Avatar

    Hi Cara, with a reaction that severe I don’t know that I’d persist. It’s all so individual. It’s often not what we think is causing the reaction at all. But, sometimes it is. There’s plenty of other anti-inflammatory foods out there to try. Ginger for example has many of the same properties.

  29. thelowhistaminechef Avatar

    Hi Cara, with a reaction that severe I don’t know that I’d persist. It’s all so individual. It’s often not what we think is causing the reaction at all. But, sometimes it is. There’s plenty of other anti-inflammatory foods out there to try. Ginger for example has many of the same properties.

  30. thelowhistaminechef Avatar

    That’s very kind of you to say Gerald, I’m glad the site has been of help!

  31. thelowhistaminechef Avatar

    That’s very kind of you to say Gerald, I’m glad the site has been of help!

  32. thelowhistaminechef Avatar

    Sarah, thanks SO much for sharing that 🙂 I’m so happy to hear you’re doing better xo

  33. thelowhistaminechef Avatar

    Sarah, thanks SO much for sharing that 🙂 I’m so happy to hear you’re doing better xo

  34. Cara Ziegel Avatar
    Cara Ziegel

    Thanks – i’m a multiple-food-allergy gal, since infancy, and apparently my grandmother had issues with (some curry spices ,my mom doesnt remember which). But I do love ginger!

  35. LeeAnn Avatar
    LeeAnn

    Yes, can’t do any dried spices right now but seem to tolerate fresh turmeric and ginger, thank goodness! I am trying the Nigella Sativa, can’t tell if it’s helping yet but I may not be taking enough. Just want to tell you that you have been my saving grace when I thought that I was going crazy these last several months. When I came across an old post of yours that was the food diary you were keeping I swear it looked exactly like mine! I kept seeing the allergist and telling him that I was reacting to all of these foods that a few months before I was able to eat with no problem. When all of my IgE and IgG tests came back pretty much showing nothing I really did think I was losing it. I love to cook and bake and I am so thankful to have found you and your recipes! I made the soup out of the AntiCookbook this weekend and it was so comforting and yummy! Thank you!

  36. cabbagejuice Avatar
    cabbagejuice

    Hi Yasmina, Thanks for the links on quercetin, very good reading, except I would doubt the one that says it can cure IBD in one week. IBD and any variation of it has had the medical establishment scratching its heads for as many years as one can count.
    My experience with bloating (up to and including yesterday) has to do with water retention and gas, also going back to childhood. The source of a lifetime of ever increasing discomfort (an understatement) must be in promoting bottle fed infants and feeding grains before the enzymes could digest them. Cow’s milk although it caused severe reactions as an infant was still poured down our throats because it was “good for you”! If the kids were sick all the time, it was obviously their fault – NOT! Horrifying soap enemas were the remedy for repeated constipation and then graduating to its opposite in adulthood.
    I actually started the SCD diet about two weeks ago but realize that histamine intolerance is a big factor with me.
    It’s so nice that there is a growing online community who are getting together in cyberspace sharing their experiences. At least it helps that we are not alone.
    And your articles are indeed very helpful and give me some hope, although it gets harder to believe in a better future as I get older and the condition just seems to get worse.

  37. Brett Avatar
    Brett

    Did I ask too many questions? Sorry. I found the TwinLabs Quercetin Plus C that you recommended elsewhere on the site. So, I just my question is just whether you’ve seen that it’s safe to take quercetin for extended periods of time. Thanks.

  38. Bea Garth Avatar
    Bea Garth

    Thanks again for an excellent article! So glad to hear your gut has gone down so significantly!! It gives me hope. I too have had basketball gut since I was a small child, like my brothers and sisters. My mother used to have us wear suspenders for when our bellies would go down! My belly is down more consistently now, but has not completed the process due I believe to continuing SIBO (which I am combatting with an artillery of herbs). I now use quercitin with tumeric, black pepper and nigella sativa with flax and pumpkin seeds daily often levened with cucumber, shredded zucchini, fresh basil, chopped celery and lettuce with fresh boiled beans. Never thought I’d eat like this, but here I am!

  39. thelowhistaminechef Avatar

    Hi Bea! Lol that sounds delicious to me, but then again it would 🙂 I’m sure you’ll get there xo

  40. thelowhistaminechef Avatar

    Hi, I’m so sorry – I spent ages writing a response and it looks like it didn’t post for some reason 🙂 If it wasn’t safe, NIH funded researcher Dr Theoharides would not have created a supplement with it. I need to update the video though because now that Twinlab is out of the quercetin I have stuck with just the Neuroprotek and I’m doing better than ever…

  41. thelowhistaminechef Avatar

    Indeed! I’m so grateful to have you all in my life xo

  42. thelowhistaminechef Avatar

    Hi love, I don’t do dried herbs anyways…great that you tolerate them! So happy to hear that you enjoyed the soup 🙂

  43. thelowhistaminechef Avatar

    So happy to hear it!!!

  44. thelowhistaminechef Avatar

    Hiya, I’m not a doc so can’t speak to dosages. I take 6 neuroprotek daily now. The NP actually has less quercetin and more of the other bioflavonoids.

  45. thelowhistaminechef Avatar

    Hi Gerald, so happy to hear it’s helping!

  46. Stacy Avatar
    Stacy

    I have to say that you are a miracle for me. I have been
    battling leaky gut, food allergies, chronic fatigue, unstoppable itchy rashes,
    acne, brain fog, insomnia and chronic rhinitis for most of my life (45). I
    finally hit rock bottom a few months ago. My doctor said there was nothing they
    could do except avoid the foods that bother me. My allergist said there was nothing he could
    do and reminded me to carry my epi pens at all times. I gave
    up on traditional medicine and started to research my symptoms myself with the
    results of my blood work in hand (which was all out of whack) and my Doctors
    all said it was just due to all my allergies and not to worry about it. This is when I decided to start an
    antihistamine diet which promptly leads me to your site. I have always said to
    people the less I eat the better I feel and now I know why. It’s not the quantity it’s the quality (rich
    in antihistamine foods). Your website and insight into this phenomenon is a
    breath of fresh air. There are many days
    I feel like I am going a little nuts. Now….I
    know I can start to heal, put on a little weight and (hopefully) regain my memory!
    😉 Thank you from the bottom of my
    heart.

  47. Jana Avatar
    Jana

    Your ebooks look really good. Which one should we start with first?

  48. Jenny Houston Avatar
    Jenny Houston

    HI Yasmina! About how old do you reckon you were in that pic? I have a just turned 5 year old with the same tummy – and suspected histamine issues.

  49. David Harrell Avatar
    David Harrell

    I’ve used quercetin for months at a time with no ill effects. (I only stop using it when I can’t afford it!) i’ve read about quercetin in dozens of sources, including vitamin reference books. I have never, ever seen even a whisper of information that there was any doubt about its safety. Quercetin is a pigment from fruits and vegetables, including onions, apples, citrus, etc. I would guess that the worst thing that could happen from taking too mich is you’d turn yellow.

  50. nasrin shah abushakra Avatar

    Dearest Yasmina!!! I am LEAKY GUT girl and have been for years, it’s nuts and I still remember you where the 1st person that believed me about it all, and I am so grateful to you. Thank YOU again and again!

  51. Ashita Avatar
    Ashita

    Hi Yasmina,
    My mother suffers from chronic urticaria,
    I would like to know what are the consequences of taking antihistamine medication for a long time? and will these medications also affect the histamine normally produced in the intestine, neurons etc?

  52. Anika Avatar
    Anika

    Do you have any more links or explanation on “some people with the COMT or MAO genetic mutations may react negatively to quercetin and turmeric”?
    Since English is not my mother tongue i’m having some problems to understand the linked medical article…. I ask because my doctor told me to take these: http://www.pureencapsulations.com/products/shop-by-product-category/view-all-by-name-274/a-i-formula.html which as i figured out now contains both ingredients you mentioned and after taking them i felt very bad. it got even worse when i was in that time of the month (getting my period) that i stopped taking them, cause i was also eating VERY histamine free, and it didn’t help. i wanted to restart taking them and give it second chance, but i really don’t dare at the moment (i guess my body and mind never felt so bad in my entire life). Thank you so much for your help.

    I see a lot of people ask for your guidance, so i appreciate it a lot!!

  53. Anika Avatar
    Anika

    Do you have any more links or explanation on “some people with the COMT or MAO genetic mutations may react negatively to quercetin and turmeric”?
    Since English is not my mother tongue i’m having some problems to understand the linked medical article…. I ask because my doctor told me to take these: http://www.pureencapsulations.com/products/shop-by-product-category/view-all-by-name-274/a-i-formula.html which as i figured out now contains both ingredients you mentioned and after taking them i felt very bad. it got even worse when i was in that time of the month (getting my period) that i stopped taking them, cause i was also eating VERY histamine free, and it didn’t help. i wanted to restart taking them and give it second chance, but i really don’t dare at the moment (i guess my body and mind never felt so bad in my entire life). Thank you so much for your help.

    I see a lot of people ask for your guidance, so i appreciate it a lot!!

  54. Lou Avatar
    Lou

    Hi , I noticed you said Quercetin did not agree with you at first…I too am having rashes with it. Did it take long to not react?

  55. Lou Avatar
    Lou

    Hi , I noticed you said Quercetin did not agree with you at first…I too am having rashes with it. Did it take long to not react?

  56. Kay Avatar
    Kay

    Brett – hope you have found some relief in the many months since your post. If not, I don’t know if you’ve looked into sulphite (or sulfite) sensitivity, but you might want to do some research. I’ve had my fair share of bloating, hives, general itching, fogginess, stomach pain, breathing difficulty. Following a sulphite free diet (or at least lowered amounts) helps me considerably. And there is likely a histamine connection to this allergy/sensitivity.

  57. Kay Avatar
    Kay

    Brett – hope you have found some relief in the many months since your post. If not, I don’t know if you’ve looked into sulphite (or sulfite) sensitivity, but you might want to do some research. I’ve had my fair share of bloating, hives, general itching, fogginess, stomach pain, breathing difficulty. Following a sulphite free diet (or at least lowered amounts) helps me considerably. And there is likely a histamine connection to this allergy/sensitivity.

  58. Julie Avatar
    Julie

    Hi Yasmina,
    Do you do anything to prepare the nigella sativa seeds before eating – such as toast them to activate the inner chemical compounds and then crush them? Or do you just eat them raw? And how much would you put in a salad? Thanks!

  59. Julie Avatar
    Julie

    Hi Yasmina,
    I’m feeling frustrated. I’ve been eating a high nutrient diet for ages. I have Crohn’s disease and my tummy is more bloated than yours in the photo. I was taking NeuroProtek religiously but then starting reacting to it and it stopped having a beneficial effect like it was before. On the ALCAT food sensitivity test I tested sensitive to turmeric and ginger. I still eat them but wonder if I should stop. Nothing seems to help me when it comes to diet. I’m guessing I have histamine and mast cell issues as my history is similar to yours and I had severe environmental illness for 15 years. Brain retraining and EFT helped immensely but still dealing with the Crohn’s and arthritis. Any ideas?

  60. Emma Avatar
    Emma

    I really want to try your anti-detox cookbook. I have been on a low amine diet for about 3 months now and am still getting as one symptoms. I have also had chronic pain for the last 2 years. Do you think trialing your recipes would be ok, and how long would I need to try them for before I knew they were working or not? I know you are not a health professional and am merely just wanting your opinion 🙂
    .I believe I have had a mast cell issue because if all the inflammation in my body and I don’t think I will get to the bottom of it with just a low amine diet.
    Thank you for doing what you do

  61. thelowhistaminechef Avatar

    Thanks love! I really like the anti-detox and anti-cookbooks xo

  62. thelowhistaminechef Avatar

    That’s so kind of you to say love. I’m so happy to hear my work has been of use to you xo

  63. Jane Avatar
    Jane

    hi .. are there sufficient recipes in your books for a vegetarian ? .. I have had IBS all my life plus rhinitis and constant brain-fog, but need a diet that I can happily follow that includes no meat or fish, no gluten (definately a trigger for me) and no onion/garlic/leek (also a trigger); would your recipes be suitable ?

  64. Mandi Santiago Avatar
    Mandi Santiago

    Both my daughter and I have the bloaty belly and EDS/ POTS (they’re starting to tie POTS to mast cell activation)! My oldest son has Mast Activation Great info, I shall have to try this! It’s always driven me nuts that when Iose weight, my face and limbs thin way out but the basketball belly remains unchanged!

  65. goodcupocoffee Avatar

    Have you tried the autoimmune protocol? I have Crohn’s as well, and since I started following this diet, my tummy bloat is much better, along with all my other symptoms! Check out the Paleo Approach Community on facebook. Or just google it if you’re unfamiliar with it. Hope you find healing!!

  66. Julie Avatar
    Julie

    Thank you for responding to me GoodCupoCoffee. I was on the Specific Carbohydrate Diet for 6 years. Diet only seems to help so much. I do a mostly Paleo diet. I have read and tried most diets dealing with gut issues. Autoimmune Paleo, GAPS, SCD, Low HIstamine, etc.

  67. goodcupocoffee Avatar

    Have you checked for Small Bowel Intestinal Overgrowth (SIBO)?
    -Allison

  68. goodcupocoffee Avatar

    Have you checked for Small Bowel Intestinal Overgrowth (SIBO)?
    -Allison

  69. Julie Avatar
    Julie

    I can’t do the test because it contains lactose. But I did 2 rounds of rifaximin with limited effects. I also take Oregon Grape Root (berberine plant) fairly regularly, and that helps a lot. But nothing has offered significant long term healing.

  70. Julie Avatar
    Julie

    I can’t do the test because it contains lactose. But I did 2 rounds of rifaximin with limited effects. I also take Oregon Grape Root (berberine plant) fairly regularly, and that helps a lot. But nothing has offered significant long term healing.

  71. Kimberly Hartman Avatar
    Kimberly Hartman

    Yasmina, this is all very helpful to me. For YEARS (like my 35 yrs of life) I have dealt with oddities and never knew why… like looking pregnant one day and flat the next and then again not able to sit upright with pants on and bloated out like a watermelon. UGH! so terrible. After yrs of reading and research and trial and error I now have the diagnoses of EDS hypermobitily type (self diagnosed and medically confirmed) and tachycardia, Chronic Urticaria and dermotographism, daily and I mean DAILY headaches/migraine, fatigue, brain fog, and ALL the signs of histamine intolerance..just to name a few of the highlights. I started reading about Mast Cell disorders and it opened up a new world of discovery for me. WOW! Who knew foods had histamine levels or ability to trigger histamine responses. FASCINATING! I started trying a low histamine diet and I’ve incorporated things like Magnesium, Vit D, Quercitin, Eve Primrose as supplements… I have been on Zyrtec for 8 yrs for my chronic, insanely itchy, over reactive skin problems and have tried to get off it dozens of times only to run back to the medicine cabinet in AGONY, unable to live a normal life off the meds. I’ve known from the start that I didn’t want to be dependent on meds…but here I was. Truly unable to live without my antihistamine. WELL, I am here to report to anyone who will listen that I have recently pushed through a week of intense agony without Zyrtec and then about 5 weeks of less itchiness each day until this week when nearly all my itchy flare-ups are gone! (My friends think I’m crazy for pushing though this, but I am DETERMINED to not live with this dependency) I am occasionally still itchy, but NOTHING compared to the nonstop insanity of scratching and welting up and burning and pain that used to characterize my days without Zyrtec. I suppose I can attribute this relief to the Low Histamine diet??? I haven’t been perfect on it, but I think lowering my levels as much as I have has obviously made a difference. I still have headaches, dizziness, and other symptoms, but I feel I have more energy and just feel more in control of my body. So, anyway, for what its worth, I am thankful that you spend your time and research in a positive way to help educate others with similar difficulties. Thanks for what you are doing! -Kim

  72. Kimberly Hartman Avatar
    Kimberly Hartman

    Yasmina, this is all very helpful to me. For YEARS (like my 35 yrs of life) I have dealt with oddities and never knew why… like looking pregnant one day and flat the next and then again not able to sit upright with pants on and bloated out like a watermelon. UGH! so terrible. After yrs of reading and research and trial and error I now have the diagnoses of EDS hypermobitily type (self diagnosed and medically confirmed) and tachycardia, Chronic Urticaria and dermotographism, daily and I mean DAILY headaches/migraine, fatigue, brain fog, and ALL the signs of histamine intolerance..just to name a few of the highlights. I started reading about Mast Cell disorders and it opened up a new world of discovery for me. WOW! Who knew foods had histamine levels or ability to trigger histamine responses. FASCINATING! I started trying a low histamine diet and I’ve incorporated things like Magnesium, Vit D, Quercitin, Eve Primrose as supplements… I have been on Zyrtec for 8 yrs for my chronic, insanely itchy, over reactive skin problems and have tried to get off it dozens of times only to run back to the medicine cabinet in AGONY, unable to live a normal life off the meds. I’ve known from the start that I didn’t want to be dependent on meds…but here I was. Truly unable to live without my antihistamine. WELL, I am here to report to anyone who will listen that I have recently pushed through a week of intense agony without Zyrtec and then about 5 weeks of less itchiness each day until this week when nearly all my itchy flare-ups are gone! (My friends think I’m crazy for pushing though this, but I am DETERMINED to not live with this dependency) I am occasionally still itchy, but NOTHING compared to the nonstop insanity of scratching and welting up and burning and pain that used to characterize my days without Zyrtec. I suppose I can attribute this relief to the Low Histamine diet??? I haven’t been perfect on it, but I think lowering my levels as much as I have has obviously made a difference. I still have headaches, dizziness, and other symptoms, but I feel I have more energy and just feel more in control of my body. So, anyway, for what its worth, I am thankful that you spend your time and research in a positive way to help educate others with similar difficulties. Thanks for what you are doing! -Kim

  73. Tracy Avatar
    Tracy

    Hi Yasmina, For those of us who can’t tolerate supplemental quercetin due
    to MAO and COMT gene mutations (I’m MAO++ & COMT++), does this mean we need
    to eliminate the quercetin rich fruit and veggies, also, or do they not react
    the same way? Did you find you could tolerate the whole foods before you could
    take the supplements? I bought your cookbooks and would like to start making
    some of the recipes. Thanks for your help. 🙂

  74. Tracy Avatar
    Tracy

    Hi Yasmina, For those of us who can’t tolerate supplemental quercetin due
    to MAO and COMT gene mutations (I’m MAO++ & COMT++), does this mean we need
    to eliminate the quercetin rich fruit and veggies, also, or do they not react
    the same way? Did you find you could tolerate the whole foods before you could
    take the supplements? I bought your cookbooks and would like to start making
    some of the recipes. Thanks for your help. 🙂

  75. fibroboston@aol.com Avatar

    Hello Julie, I was curious if you can share what you say when you tap for the mast cell or histamine intolerance. Thank you so much!

  76. fibroboston@aol.com Avatar

    Hello Julie, I was curious if you can share what you say when you tap for the mast cell or histamine intolerance. Thank you so much!

  77. Julie Avatar
    Julie

    I did EFT for chemical sensitivity, not histamine or mast cell issues specifically.

  78. Julie Avatar
    Julie

    I did EFT for chemical sensitivity, not histamine or mast cell issues specifically.

  79. T.M. Anderson Avatar
    T.M. Anderson

    Can you please explain how you were able to get to the place where you are fine with quercetin and tumeric with COMT and MAO genetic mutations? What did you have to do to get your body to react positively to them instead of negatively? Thanks.

  80. T.M. Anderson Avatar
    T.M. Anderson

    Can you please explain how you were able to get to the place where you are fine with quercetin and tumeric with COMT and MAO genetic mutations? What did you have to do to get your body to react positively to them instead of negatively? Thanks.

  81. Lisa Mary T Avatar
    Lisa Mary T

    I am kicking my overconsumption of bone broth to the curb. This may be why too much is not good for me. http://www.heartfixer.com/AMRI-Nutrigenomics.htm#Glutamate – GABA Imbalance Þ Excitotoxicity.

  82. Lisa Mary T Avatar
    Lisa Mary T

    I am kicking my overconsumption of bone broth to the curb. This may be why too much is not good for me. http://www.heartfixer.com/AMRI-Nutrigenomics.htm#Glutamate – GABA Imbalance Þ Excitotoxicity.

  83. Lisa Mary T Avatar
    Lisa Mary T

    Another great link supporting kicking bone broth to the curb http://www.holistichelp.net/blog/how-to-increase-gaba-and-balance-glutamate/

  84. Lisa Mary T Avatar
    Lisa Mary T

    Another great link supporting kicking bone broth to the curb http://www.holistichelp.net/blog/how-to-increase-gaba-and-balance-glutamate/

  85. thelowhistaminechef Avatar

    Hi there, honestly I have no magic formula to share sorry. I just focused on getting healthy rather than continuing to bang my head against the wall with diagnosis or any specific healing protocols. I ate lots of prebiotic foods, lots of generally healthy foods, lots of juicing.

  86. thelowhistaminechef Avatar

    Hi there, honestly I have no magic formula to share sorry. I just focused on getting healthy rather than continuing to bang my head against the wall with diagnosis or any specific healing protocols. I ate lots of prebiotic foods, lots of generally healthy foods, lots of juicing.

  87. thelowhistaminechef Avatar

    Indeed! Thanks for the links, others may be interested.

  88. thelowhistaminechef Avatar

    Indeed! Thanks for the links, others may be interested.

  89. thelowhistaminechef Avatar

    Hi love, honestly I don’t have the answer to that. I know many with the mao avoid turmeric, but I don’t know about the others sorry…

  90. thelowhistaminechef Avatar

    Hi love, honestly I don’t have the answer to that. I know many with the mao avoid turmeric, but I don’t know about the others sorry…

  91. dkaj Avatar
    dkaj

    Dear Yasmina, in your post you said you kicked l-glutamine to the curb. Is L-glutamine not good for histamine intolerance and mast cell issues?? I keep reading contradictory info on this supplement. Can you state whether or not it is recommended and why. TIA

  92. Elisa Avatar
    Elisa

    I have the anti cookbook. I would love to find out more how you healed your gut… Just eating low histamine and high nutrient?

  93. Elisa Avatar
    Elisa

    I have the anti cookbook. I would love to find out more how you healed your gut… Just eating low histamine and high nutrient?

  94. Viktor Avatar
    Viktor

    I think you had sibo belly rather than leaky gut belly.

Leave a Reply

Your email address will not be published. Required fields are marked *

More Articles from Healing Histamine

  • Best Outdoor Finger Foods

    Best Outdoor Finger Foods

    There’s nothing like light-hearted summer get-togethers in the backyard or out on the deck fueled by delightful and delicious finger foods. For the histamine intolerant guest, chips and salsa are…

    Read more

  • Best Histamine Intolerance BBQ Foods

    Best Histamine Intolerance BBQ Foods

    Summertime is BBQ time. There’s nothing like the smell of hot food fresh from the grill and an al fresco meal with friends or family to wrap up a hot…

    Read more

  • The Hay Fever-Histamine Connection

    The Hay Fever-Histamine Connection

    Hay Fever, otherwise known as allergic rhinitis (nasal allergies), or what most people refer to simply as “allergies” has an association with histamine intolerance and mast cell disorders. Have you…

    Read more

  • Histamine & The Pool or Beach

    Histamine & The Pool or Beach

    When it’s hot and sticky in the summertime, there’s nothing like a dip in the pool or a trip to the beach to cool you down. And since histamine intolerance…

    Read more

  • This Parasite Triggers Histamine Intolerance

    This Parasite Triggers Histamine Intolerance

    Could parasites be causing or contributing to your chronically high histamine levels? We know that imbalances in the gut microbiome can cause histamine problems, but how about intestinal parasites? It’s…

    Read more

  • 6 Summer Histamine Challenges and Solutions

    6 Summer Histamine Challenges and Solutions

    Summertime is a wonderful time of being outside, taking in the sunshine, mowing the lawn, and enjoying cookouts with friends and family. However, for those of us dealing with histamine…

    Read more

  • Boost Good Gut Bacteria Without Supplements

    Boost Good Gut Bacteria Without Supplements

    Most of us know that our gut plays an important role in our immune response. The levels of different species and strains of bacteria in the gut, and especially which…

    Read more

  • Exercising with Histamine Intolerance

    Exercising with Histamine Intolerance

    We all know exercise is recommended for a healthy body in the long run. However, with histamine intolerance, you’re probably finding that exercise can make you sick. Unfortunately, exercise over…

    Read more

Welcome!

Yasmina was an award-winning broadcast journalist with a decade of experience covering war zones for CNN and the BBC. She devoted her journalism skills to researching and writing about histamine. Click here to learn about her. Each post is carefully and fully referenced with the latest scientific research. Not sure where to start? Here’s a four week meal plan and overall Histamine Reset.


4 Week Histamine Reset


Recent posts



Anti-Recipes…Bioflavonoid Rich & Hearty Foods $18

GET STARTED HEALING HISTAMINE

WHAT YOU NEED TO KNOW ABOUT HISTAMINE DELIVERED TO YOUR INBOX