Tag: diamine oxidase

  • Holy Basil! Anti-inflammatory and anti-histamine superstar

    Holy Basil! Anti-inflammatory and anti-histamine superstar

    Basil flowers in the garden

    Not only is Holy Basil tasty in just about any Thai or Vietnamese dish – turns out it’s an anti-inflammatory, anti-histamine herb that’s as effective as Ranitidine/Zantac at treating H2 (histamine) induced ulcers, preventing mast cell degranulation and anaphylactic shock. How do’you like them apples?

    I like Holy Basil a lot better than them apples…but just to clear up any potential confusion, Holy Basil is also known as Sweet Thai Basil or by it’s proper names: Ocimum tenuiflorum and Ocimum sanctum. (source: Wikipedia)

    Holy Basil’s activity as an anti-histamine has been found to affect histamine’s H2 receptor, great news for those with histamine intolerance/histaminosis/mastocytosis/mast cell activation disorders with gastrointestinal complaints. I’d be interested to know if it’s anti-inflammatory effects are in part due to it’s high Vitamin K content. Don’t forget that Vitamin K (as I mentioned in this post), is a potent anti-inflammatory, is found in many foods like cauliflower, which is also high in Vitamin C.

    Holy Basil prevents mast cell degranulation, helping treat allergic disorders

    “Basophils, mast cells, and their preformed de novo synthesized mediators, play a pivotal role in the pathogenesis of allergic disorders. These molecules are potent vasoactive and bronchoconstrictor agents and they modulate local immune responses and inflammatory cell infiltration (17-18).Immunoglobulin E (IgE)-mediated mast-cell stimulation is an important initial event in the development of type I allergic reactions such as asthma and atopic disorders. Clinical studies have found a close association between asthma and serum IgE levels, as well as IgE-dependent skin test reactivity to allergens. Antigen challenge, in sensitized animals, results in the degranulation of mast cells, which is an important feature of anaphylaxis. O. sanctum ethanolic extract showed marked protection against the mast cell degranulation following antigen challenge in sensitized animals. Mast cell stabilizing activity of extract may be attributed to the presence of anti-inflammatory mediator release, which is known for their mast cell stabilizing potential against antigen-antibody reaction and/or due to the suppression of IgE antibody production, which is responsible for degranulation mast cells. This antianaphylactic and antihistaminic effect may be due to the stabilization of the mast cell membrane, suppression of IgE, and inhibition of pathological effects induced by the release of inflammatory mediators in test extract treated animals.

    Experimental results indicated the potent benefits of O. sanctum in the treatment of asthma and related conditions. The findings from various studies reveal that the antihistaminic and antianaphylactic activity of extract which is mainly due to its mast cell stabilizing potential, suppression of IgE, and inhibition of release of inflammatory mediators. Thus use of O. sanctum leaves proved the strong rationale behind the mentioned therapeutic activities [1].”

    Holy Basil is as effective as Ranitidine/Zantac at treating H2 receptor induced GI complaints

    “This study was conducted with the aim of comparing the efficacy of ocimum sanctum against gastric and duodenal ulcers. The hydralcoholic extract of the plant exhibited significant ulcer protective effect against gastric ulcers in pyloric ligated rats as well as against duodenal ulcers in histamine treated guinea pigs. In both these models of peptic ulcer, significant ulcer protective effects were observed with 100 mg/kg and 200 mg/kg of ocimum sanctum, which were comparable. These effects were also comparable with ranitidine which was used as the standard drug for comparison in both the models. The antiulcer activity of ocimum sanctum could be due to its antisecretory, anticholinergic or antihistaminergic properties. In view of this therapeutic potential, more studies are required to establish ocimum sanctum as a standard drug for peptic ulcer [2].”

    They’re using high amounts of Holy Basil in the studies.What do you think? Would you consider adding Holy Basil to your diet as an anti-inflammatory or histamine blocker to help treat your histamine intolerance, histaminosis, mastocytosis or mast cell activation?

    WONDERING HERE TO START? HERE’S A FOUR WEEK COURSE & MEAL PLAN TO TAKE THE STRESS OUT OF HEALING HISTAMINE

    Please don’t forget antihistamine, pain killing foods can still hurt us, so please always check with your doctor before adding new foods to your diet. 

    ————REFERENCES—————

    [1] http://www.ispub.com/journal/the-internet-journal-of-pharmacology/volume-7-number-1/pharmacological-basis-for-antianaphylactic-antihistaminic-and-mast-cell-stabilization-activity-of-ocimum-sanctum.html

    [2] http://www.ispub.com/journal/the-internet-journal-of-gastroenterology/volume-11-number-1/comparison-of-efficacy-of-ocimum-sanctum-against-gastric-and-duodenal-ulcers-in-animals.html

     

  • Exercise is good for you, so why does it make you sick?

    Exercise is good for you, so why does it make you sick?

    New studies show that aerobic exercise raises histamine levels. This isn’t news to me. When playing squash I have to take time outs to scratch myself silly and wait for the room to stop spinning. My man, now used to such bizarre-isms, plays against the wall for a while till it calms down again. I looked a lot crazier, to a much larger crowd, during our recent trapezing class! I’m sure I can thank adrenaline for that…What really interested me in this particular study is that they determined resistance training (weights/yoga) doesn’t raise histamine levels. They highlight how histamine released by aerobic exercise causes significant vasodilation (the widening of blood vessels in the body).This study ties in nicely with last week’s post about histamine being a vasoactive amine that can increase or decrease heart rate and induce anxiety-mimicking symptoms.

     

    *Resistance training is any exercise that causes the muscles to contract against an external resistance with the expectation of increases in strength, tone, mass, and/or endurance. The external resistance can be dumbbells, rubber exercise tubing, your own body weight, bricks, bottles of water, or any other object that causes the muscles to contract. http://www.emedicinehealth.com/strength_training/article_em.htm

    Interestingly, I meeting quite a few people who are being prescribed anti-histamines by their docs to deal with asthma/wheezing, abnormally high heart rate and passing out while exercising. Wouldn’t it be simpler to go on a low histamine diet? Probably not, but it would yield better (healthier) results!

    What does this mean for your work out routine? 

    Aerobic exercise, like my current favorites kickboxing and squash, can significantly raise histamine levels in the body. The upside (because in my world there always is one) is that people pay good money for pharmaceutical vasodilators to lower their blood pressure. The downside (other than the spike in histamine for those of us with histaminosis/histamine intolerance), is the migraines that accompany vasodilation. I often get migraine like headaches if it’s too hot in yoga class.

    Does this mean I shouldn’t exercise?

    I’m asked this a lot, usually by life long couch potatoes!

    What I take from this study is that it might be a good idea, if you’re suffering from histaminosis/histamine intolerance, to explore “non dynamic” exercise like weight training, or my perennial favourite, yoga. Speaking of which, did you know that one of the many studies on yoga showed that females who practiced yoga regularly had 41% lower stress markers than non-yogis? And significantly lower inflammation! Given that inflammation (caused by high histamine) is a huge concern to those of us with histaminosis/histamine intolerance, it’s food for thought the next time you’re crashed out on the sofa telling yourself that exercise is bad (while contemplating another root around the fridge).

    So what’s a histamine-challenged gal to do?

    We’ve all been there, but there’s really no time like the present for a full body/mind make over. Try waking up tomorrow and investing in a yoga mat and a $15 subscription to Yogaglo online classes. I promise you won’t regret it.

    Don’t forget to sign up to my newsletter for free recipes and a 10% discount on ebooks…and why not check out how I keep my histamine level in check and stay anti-histamine free with my low histamine DAO Support Recipe Book and The Low Histamine Desserts Book?

  • Histamine’s upside: I lost 35kg (77lbs) in 6 months!

    Histamine’s upside: I lost 35kg (77lbs) in 6 months!

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  • Got allergies? Homeopathic remedy reduces histamine-induced inflammation

    Got allergies? Homeopathic remedy reduces histamine-induced inflammation

    Natural caduceus bottle concept

    I’m usually on the fence about homeopathic remedies. I’d love to believe they work, but have yet to see the studies backing up their claims. Today however I found a study showing that a homeopathic remedy, Rhus Toxicodendron, “significantly reduces” carrageenan induced inflammation in rats. As I mentioned in another post, carrageenan (irish moss) is a seaweed derived food additive that is also frequently used in raw food desserts . 2016 update: sorry I should say that irish moss is used in raw foods, not carrageenan. Carrageenan is however found in many organic and natural foods as well as toothpaste.

    The study authors note: “We found significant reductions compared to control in carrageenan-induced paw oedema, vascular permeability, writhing induced by intraperitoneal acetic acid and stress induced gastric lesions. Rhus tox in homeopathic dilution appears to interfere with inflammatory processes involving histamine, prostaglandins and other inflammatory mediators.” But that doesn’t mean upping the dose will get you more inflammation relief, on the contrary…”Administration of a single dose of Rhus tox 1h prior to injection of Carrageenan significantly reduced the paw inflammation in a dose dependent manner. Administration of multiple doses of Rhus tox increased the intensity of inflammation induced by Carrageenan, but this was not statistically significant. [1]

  • Unexplained weight gain? Dr. Oz blames hidden food allergies!

    Ok here’s one I totally relate to. Dr. Mehmet Oz, on his show, recently explained how hidden food allergies can make you gain up to 30lbs (20kg) a YEAR.

    food allergies make you fat!
    food allergies make you fat!

    Here’s Dr. Oz on his show explaining how, when faced with an undiagnosed allergy whereby the good bacteria cannot process the food (I think maybe he’s referring to the histamine degrading enzymes diamine oxidase, monoamine oxdase and HNMT) the body responds with inflammation that quickly distends the bowels, stomach and surrounding areas, adding up to 30 pounds (20 kilos) of weight EVERY YEAR.

    “Gulp”. Yes, I have experienced that first hand. I finally lost 35 kilos (77 lbs) over two years ago, as a result of going on a low histamine diet. I lost the equivalent of a small person!

    I attribute some of the weight loss to stopping the anti-histamines which were making me eat like a football player. A football player who has been wandering the dessert without food for two weeks, with only a bag of ganja to sustain him. Yeah, I was obsessed with food, allergenic food that was causing inflammation thanks to a lack of histamine-degrading diamine oxidase, monoamine oxidase and others. But even before then, my friends were always as baffled as I by my weight gain. Was I eating in secret? Was I sleep eating? These were valid questions but I wasn’t.

    I can’t say I haven’t become healthier overall since going low histamine, because I definitely have, but my calories aren’t that much lower now. I even eat more dessert now than I used to, which brings me back to how to pig out without gaining weight. Can you guess?? Yup, my first dessert book is finally out! The Low Histamine Dessert Book is gluten-free, milk-free and refined sugar free. All low histamine desserts have been tested out on my non-amine challenged friends…this is the good stuff that I break out for tea, after dinner treats and kiddie birthday parties! The moist chocolate (make it with carob or cacao, there are instructions for both) is perfect for birthdays, and no one has no come back for seconds of the delicious almond butter cupcakes. Though you can frost them with anything…

    You can download the low histamine dessert book here. If you’re dealing with histamine-induced weight gain from anti-histamines, histamine intolerance, histaminosis or mastocytosis, you might want to check out my Low Histamine Diamine Oxidase Support Cookbook first!

  • Fox News report on histamine intolerance covers mood/depression link!

    Fox News report on histamine intolerance
    Fox News report on histamine intolerance

    Fox News is the first major player to cover histamine intolerance (histaminosis).

    Interestingly the link between histamine disorders and mood/depression are mentioned in the report.

    Check out the full story here.

  • Food additive sensitive ADHD kids may lack histamine-degrading HNMT enzyme

    Food additive sensitive ADHD kids may lack histamine-degrading HNMT enzyme

    Lack of a histamine-degrading enzyme linked to ADHD in kids

    Children lacking the HNMT gene responsible (along with Diamine Oxidase) for degrading histamine in the body, are likely to suffer an increase in adverse reactions to food additives and colorings, which may exacerbate existing ADHD [1]. I have a feeling we’ll be seeing many more studies making a stronger case for food additives and colorings being implicated in all kinds of behavioral disorders in children.

    Dr. Emily Deans on her blog Evolutionary Psychiatry had this to say about the study: “Overall, the three year-olds had significant reactions to the hyper juice (more Mix A than Mix B) if they lacked certain alleles of the histamine N-methyltransferase (HNMT) gene.  There seemed to be no differences in the reactions depending on the dopamine or other checked genotypes.   In the 8/9 year-olds, the results were quite similar.  Not too much difference when dopamine may be off, but a significant difference depending on the HNMT gene allele.”This is not only the first study I have seen definitively making a link between behavioral problems in children and food additives, but also the first one linking histamine to it. Though it wasn’t a huge sample (less than 300 kids) and was not a long term study, I’m sure we’ll be hearing a lot more in the near future.

    As someone who can attest to the mania inducing effects of food additives and colouring, I sincerely hope that parents around the world will pay more attention to what they put in their children’s bodies, whether influenced by histamine or not. My uncle had a very simple rule with his kids in the supermarket. You can have it if you can pronounce every word on the food label! His kids were well into their teens before getting their first taste of nasty foods. By that time their taste buds were well formed enough to know that it was poison. They’re two of the healthiest eaters I know (other than their parents!).

     I’d love to hear from you if this study correlates with your own experiences and if you’ve had success treating your child through a low histamine, low amine, or dye/preservative free diet.

    It’s finally here! Man Food – a high nutrient antihistamine and anti-inflammatory ingredient filled book geared towards guys, women who love to work out, yoga like they mean it, or just load up on healing nutrients. Features my personal shopping list of antihistamine and anti-inflammatory foods. 

    The Anti-cookbook and all liquid Anti-Detox Book, don’t treat any conditions, but feature a plethora of the high nutrient antihistamine and anti-inflammatory ingredients that have been instrumental in helping me feed myself on a limited diet. The Anti-cookbook features a six page list of antihistamine and anti-inflammatory foods and comes in regular and Paleo. 

    The Low Oxalate Cookbook features antihistamine and anti-inflammatory rich recipes. 

    Don’t miss the Low Histamine Beauty Survival Guide for non-toxic beauty tips, the skinny on histamine releasing (mast cell degranulating) beauty ingredients, antihistamine and anti-inflammatory beauty alternatives and the top brands natural brands I’ve found.

    Take a peek at my other low histamine and antihistamine cookbooks for more high nutrient recipes

    ———-REFERENCES———-

    [1] http://www.ncbi.nlm.nih.gov/pubmed/20551163

  • Histamine induced uterine contractions a danger in pregnancy.

    Histamine & pregnancy
    Elevated histamine levels can affect pregnancy

  • Irresistible to the opposite sex? Histamine could be why!

    Estrogen causes histamine release

    Estrogen can cause major histamine release in the body. Now why would you want that? Because histamine makes you um, randy, and your biological imperative is to procreate. We shouldn’t really complain though,estrogen makes us more attractive to the opposite sex…but back to my point.

    Studies on female rats show that estrogen supplementation, or natural fluctuations in cycle near ovulation, cause libido boosting histamine release. Didn’t know that histamine affects your sex drive? You’re welcome! Please explain to your significant other that spiking your meals with cashews isn’t necessary thank you very much. It’s one of the many perks/crosses to bear with our histaminosis/histamine intolerance diagnosis.

    Estrogen is important in female precopulatory behaviors in 3 m ways: 1) estrogen increases a female’s willingness to approach a male to induce solicitatious behaviors, 2) estrogen can enhance the “attractivity” of the female: estrogen priming can induce the production of stimuli that make her more attractive to the male (odors or pheromones, vocalizations), and 3) estrogen ‘primes’ for progesterone.

    So…

    (more…)
  • Vulvodynia, histamine, oxalates and diet

    Vulvodynia, histamine, oxalates and diet

    Is pain “down there” ruining your life? You’re not alone. Chronic “lady pains” were a hot topic at the hista-sista kvetch-sesh in Notting Hill yesterday. The abundantly histamine blessed ladies and I compared notes. The term “chronic pelvic inflammation” of idiopathic origin and vulvodynia came up quite a bit, as did its disastrous effect on mental health and intimacy with our partners.

    I went home and did some research. Obviously, there was a link. It’s something that almost every single woman with histamine issues (that I’ve been brave enough to ask) has complained of.

    Here’s what I found:

    “Our data suggest that women with a history of urticaria, seasonal allergies or reaction to insect stings appear to be more prone to later development of vulvodynia than women with no history of these allergic reactions. We also showed that this association was largely confined to exposures that occurred before the first onset of vulvar pain, suggesting that allergenic exposures could be involved as, or a marker of, factors involved in the development of vulvodynia. We also observed that a history of other skin conditions, not as strongly related to an immune response, generally were not associated with the risk of vulvodynia. [1]”

    And…

    “Vulvodynia is a complex disorder and described as discomfort or intense burning pain in the vulvar area. Such chronic pain affects 5 to 15% of women and many suffer of misdiagnosis. For sure the aetiology is multifactorial. Through few studies we consider the inflammatory response plays a major role. There is a genetic profile of women suffering of vulvodynia, especially genetic polymorphisms from genes coding for cytokines, Interleukin-1 receptor antagonist and Interleukin-1 beta, and gene coding for mannose-binding lectin (MBL). These polymorphisms result in a stronger inflammatory response and lay these women in a susceptibility situation. Histological analysis showed a chronic non specific inflammation. We have also demonstrated that these patients present in normal state or under infectious induction an inadequate inflammatory response. But there is still a variety of mechanisms which can interact with the inflammatory response. Management of such vulvar pain syndrome could be very frustrating, but the first step for improvement is to get the right diagnosis [2].”

    What I found particularly healing was cutting down on high oxalic acid foods like curly kale and most grains. That cleared up much of my bloating, interstitial cystitis and general sense of malaise. It took a while, but was worth it. I hadn’t realised initially that oxalates were as big an issue for me as histamine. I highly recommend getting tested if you feel this is your issue. You can check out my oxalate post here.

    Click here to learn how to create your own healing histamine diet. 

    All the more reason to look after your health/diet and be good to yourself (lady parts included). I’m off to make a very low histamine anti-inflammatory dinner – you’ll find plenty of recipes in my Man Food book there’s also lots of information and low oxalate recipes in my Low Oxalate Cookbook.

    It’s finally here! Man Food – a high nutrient antihistamine and anti-inflammatory ingredient filled book geared towards guys, women who love to work out, yoga like they mean it, or just load up on healing nutrients. Features my personal shopping list of antihistamine and anti-inflammatory foods. 

    The Anti-cookbook and all liquid Anti-Detox Book, don’t treat any conditions, but feature a plethora of the high nutrient antihistamine and anti-inflammatory ingredients that have been instrumental in helping me feed myself on a limited diet. The Anti-cookbook features a six page list of antihistamine and anti-inflammatory foods and comes in regular and Paleo. 

    The Low Oxalate Cookbook features antihistamine and anti-inflammatory rich recipes. 

    Don’t miss the Low Histamine Beauty Survival Guide for non-toxic beauty tips, the skinny on histamine releasing (mast cell degranulating) beauty ingredients, antihistamine and anti-inflammatory beauty alternatives and the top brands natural brands I’ve found.

    Take a peek at my other low histamine and antihistamine cookbooks for more high nutrient recipes.

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