Dr Joneja: How to boost your histamine-lowering DAO enzyme (naturally)

Pea Sprouts

Download Dr. Joneja’s guide to growing DAO rich sprouts here: Pea seedlings as a supplement

As I outline in my first book, a diet rich in vitamin B6, magnesium, copper and other nutrients is necessary in order for our body to produce the histamine-lowering enzyme DAO (diamine oxidase).

But, I neglected to mention another (delicious) source of natural DAO – mainly because I’m not a freaking scientist and I wasn’t sure what I’d found…

I digress.

Many of you write to me (oh so many) asking me if I take DAO supplements. I do not. Then I’m asked if I endorse them. I do not. I did, for a couple of years, take a natural DAO supplement made from a vegetarian source (many of the supps on the market use pork glands). Sadly that DAO supplement never made it to market.

I’m not saying I wouldn’t have continued taking them if they had hit the health food store shelves, but honestly, at that point I had become militantly anti-supplement and took absolutely nothing. I was determined not to mess with my body. I just wanted to give it some time to breathe, to remember how to heal itself:

“Our body is a machine for living. It is organised for that, it is its nature. Let life go on in it unhindered and let it defend itself, it will do more for you than if you paralyse it by encumbering it with rememdies.” – Leo Tolstoy.

I’m a huge fan of this quote, but honestly, there came a time where I wondered if I could speed up the healing process by just adding one or two. And so I did…you’ll find a video on the best supplements I tried here and you can find all of those items in my amazon store.

I had all but forgotten this piece of surprising research I came across a few years ago (filed in my “find a doctor to comment on this” folder), when just a few days ago I was blessed with a wonderful email from the fabulous immunologist, nutritionist, author and histamine researcher Dr Janice Joneja. For those of you who haven’t yet, you MUST read this groundbreaking interview on histamine intolerance with Dr Joneja.

Says Dr Janice Joneja:

“I have a number of patients who cannot take these (DAO) supplements because they are allergic to pork, or cannot consume them for religious or cultural reasons.  The commercial sources of DAO are derived from pig kidney and those allergic to pork tend to develop quite severe allergic reactions to the products.

In my research, I have identified a plant source of DAO: pea seedlings.  A number of years ago I tried to interest several agencies, including University departments, in conducting research into extracting DAO from pea seedlings and concentrating it into a pill or powder as an alternative to the pork-based products.  Unfortunately, none of these considered the project to be worthwhile because they had to weigh the cost of the research against the projected profits from such a product.  Yesterday I had a long conversation with a patient who is allergic to pork and had a strong reaction to a DAO supplement. We discussed the possibility of sprouting green peas and consuming the sprouts regularly to determine whether this might help with her histamine intolerance symptoms.  I had the intention of cultivating the sprouts from fresh peas myself.  Rather fortuitously, I was shopping at my local market this morning and came across pea shoots.  I had never seen the product previously.  It is sold under the FarmFresh brand.  This is a Canadian product made by Nankia Sprouts Corp. In practical terms, of course, it would be much cheaper for a person to sprout the peas themselves, using the same method as used for sprouting mung beans or alfalfa. However, this product could be an alternative for those not interested in going to the extent of cultivating the seedlings themselves.

As you have a large number of histamine-sensitive people who follow your management strategies, I was wondering whether we could enlist their help in determining whether pea seedlings could aid in reducing their symptoms by increasing their DAO from this source.  It would be relatively inexpensive, would increase their dietary sources of many nutrients, and be safe as far as adverse reactions are concerned.  In addition, this would be the first time that a method of increasing DAO other than the commercial brands of supplements has been attempted.”

I don’t know about you, but eating my medicine has always been my top choice, so this email actually made me squeal with excitement (those of you who have met me know this is a literal description – I have the girliest squeal).

So, hista-sistas and mistas, what do you think? Should we guinea pig ourselves in the name of science?

You know my answer – I’ve been doing it for years!

Please join our Facebook group where we’re comparing our experiences and collecting data for Dr Joneja so she can get a medical study going.

Be well friends, don’t forget to sign up to my newsletter to be the first to know about upcoming histamine wellness retreats and workshops in Europe and the United States, to get great freebies like antihistamine and anti-inflammatory recipes and lifestyle tips. 

The Anti-cookbook, while it doesn’t treat any conditions, due to its high nutrient, antihistamine and anti-inflammatory ingredients, has been instrumental in helping me feed myself on a limited diet. It features a six page list of antihistamine and anti-inflammatory foods. It comes in regular and Paleo. 

The Low Oxalate Cookbook features antihistamine and anti-inflammatory rich recipes. 

Don’t miss the Low Histamine Beauty Survival Guide for non-toxic beauty tips, the skinny on histamine releasing (mast cell degranulating) beauty ingredients, antihistamine and anti-inflammatory beauty alternatives and the top brands natural brands I’ve found.

Take a peek at my other low histamine and antihistamine cookbooks for more high nutrient recipes.

If you’ve found this information useful I’d appreciate your support (at no extra cost to you!) – please check out my online store for your health foods, supplements, kitchen items and beauty product purchases. Affiliate sales through my online store go towards maintaining the website, funding travel to interviews and purchasing all the lovely foods for my free online recipes. You’ll find these items in the “Shop with us” drop down menu on my homepage.  

Please don’t forget antihistamine, pain killing foods can still hurt us, so please always check with your doctor before adding new foods to your diet. 

 

74 responses to “Dr Joneja: How to boost your histamine-lowering DAO enzyme (naturally)”

  1. tony bruce Avatar
    tony bruce

    exogenous histamine in the form of dilute histaglobulin is therapeutic to mast cell h2 and h3 receptors, allowing them to make dao and other enzymes to shut off the interminable cracking up of histamine granules in the h1 receptor.
    i was at death’s door, weighing in at 58 kg (i am 1.87m tall, that is 6’1″ and 9 stone). since i began subcutaneous injections of histaglobulin at the allergists dilution of 7(which is about 1/750,000) about 2 months ago, my terrible headaches have disappeared and i have put on almost 12 kilos(about 2 stone).
    histaglobulin is the substance that allergists use as the control when doing skin tests but for some bizarre reason most fail to include it in your allergy shots.
    by all means, continue to eat healthily, do yoga, meditate, love….but get to an allergist and try this. it is a little difficult getting the dosage right as the skin tests are not entirely indicative of your body’s internal state, but right now i feel as if i’m getting my life back and really think that most of you could too!
    there is a book, unfortunately out of print, that describes all of this in great detail. “the plot against asthma and allergy sufferers”, by felix ravikovich m.d. some used copies are available on amazon in uk.

  2. Christine Jurew Avatar
    Christine Jurew

    Thanks for passing this along Yasmina, I’m looking forward to trying this! Wondering how much to consume for effectiveness.

  3. jane Avatar
    jane

    Hi do you live in uk as would love to try this

  4. Julie Avatar
    Julie

    This is great to know! I’ve been eating pea shoots in fresh veggie juices and salads for years. Yay!!

  5. Clarissa Kelly Avatar
    Clarissa Kelly

    Fantastic idea! I have peas just starting to grow in my garden, will harvest some shoots soon! I also could grow the sprouts indoors once I have a method. I have always loved to eat the new shoots, so this gives me another incentive entirely! Yay! 🙂

  6. Blue Avatar
    Blue

    Sounds like a brilliant idea… I don’t suppose you know if they’re high in sals or not?
    Cheers
    Naoimh

  7. T.H. Avatar
    T.H.

    Oh, absolutely!

  8. Kelly Avatar
    Kelly

    Are the subcutaneous injections you are doing called EPD or LDA therapy?

  9. RS Avatar
    RS

    I’m willing to try it. I just need to find some organic peas to buy.

  10. Sandra Pawula Avatar
    Sandra Pawula

    Peas contain glutamine so I know I definitely can’t eat them or pea protein. I always though sprouting increase the histamine level of a plant. So I’m not sure about this. I’ll be curious to see the outcome.

  11. thelowhistaminechef Avatar

    That’s too bad. Yes, sprouts, especially if mishandled, can have higher histamine, but as I always say, not all histamine is bad for us. I’ll keep you posted 🙂

  12. thelowhistaminechef Avatar

    I believe they are sadly (according to a friend who’s sals sensitive). Other sprouts also have DAO. A little google should turn up some answers 🙂

  13. thelowhistaminechef Avatar

    That’s wonderful!!

  14. thelowhistaminechef Avatar

    I haven’t heard of any doctors doing this in the UK. It’s highly controversial. I was going to try bee venom therapy (same principle) but I was concerned with the safety as it’s much harder to control how much histamine you’re getting. I know when I’ve been stung this last year, I experienced a remission of symptoms in the following weeks. I don’t however recommend it!

  15. thelowhistaminechef Avatar

    🙂 I think that’s what we’ll have to work out individually…

  16. thelowhistaminechef Avatar

    Hi Tony, yup read the book in 2010 when I was first diagnosed. You used to be able to buy it from his website. Fact is, I am against all kinds of medical intervention, especially one that we have no idea of the consequences of. This treatment manipulates the immune system, something I’m not willing to toy with. I did explore the idea of bee and snake venom therapy (essentially the same idea) but balked at the lack of dosage control. I’m happy it’s working for you. Could you please email me the allergist’s details so that I can interview him? Though I don’t like medical intervention, I am happy to guinea pig myself in case it does work and is of interest to my readers.

  17. Anna Walden Avatar
    Anna Walden

    Found them at the co-op where I shop! Yay!!

  18. Jodi Owen Avatar
    Jodi Owen

    I’m always up for an experiment. I didn’t tolerate sprouted mung beans though, so I’ll proceed with cautious optimism. 😉 Glad I didn’t get rid of my germinating jar…

  19. yacurama Avatar
    yacurama

    I tried a DAO supplement, didn’t react to it, but it had no effect :/ But maybe the peas work? I’ll give this a try!

  20. Aleks Avatar
    Aleks

    I’ll give it a try. I wonder whether snow peas also have high DOA? Or is it regular peas? Looking forward to the instructions.

  21. Klkane Avatar
    Klkane

    I am the patient Dr Joneja is talking about in this article…we are going to start trials soon…I believe this is a reasonable source of building DAO and it has been researched before, although it has less of the enzyme compared to the porcine source, it is still a viable choice especially for people like me who do not do well with pork, or vegetarians and the like. My only concern is that peas are a excitotoxin…and it doesn’t go well with my methylation protocol…but I am willing to give it a go.

  22. Debbie T Avatar
    Debbie T

    I’m excited about the possibility. I’ll be anxious to hear about the results.

  23. tony bruce Avatar
    tony bruce

    i don’t think so, they call it intradermal provocation neutralising treatment or something like that, but i have not followed their specific treatment programme. i have been taking only histamine, their treatment would have involved many other allergen extracts…

  24. tony bruce Avatar
    tony bruce

    i am going to the burghwood clinic in sutton, surrey. but good luck getting an appointment at this time of year! i would have thought that any allergist would have histaglobulin in stock as it is their control substance for skin testing. wether they will put it in an allergy shot for you is a different question…this is not an easy thing to do as you can have some bad results, and in this litigious age doctors tend to err on the side of caution to avoid potential ruin.
    doctors today are taught by the pharmaceutical companies to list symptoms and line them up with the appropriate drugs. if they stick to these prescriptions, no matter what happens, they are in the clear. you can die, it doesn’t matter: they followed the rules.
    if they deviate from the pharma-led doctrine and you get a headache, you can sue them. so they are really in a bind too….

  25. tony bruce Avatar
    tony bruce

    so funny, about 5 years ago i went to india for 3 months. i was really scared about the headaches i had been getting(i took bumper amounts of antihistamines with me) on the first day i was stung by a wasp and had no problems during the trip. i only really just remembered the sting when i read this post 🙂
    btw antihistamines are cytotoxins, prolonged use of which will totally destroy your mast cells. ditto steroids.

  26. Audrey Walker Avatar
    Audrey Walker

    Wow, this is great news for vegetarians! I’ve never tried sprouting but I know its very cheap and can’t be that hard. I’m very excited to try this!

  27. jane Avatar
    jane

    Hi Tony I just wondering what condition you have that enabled you to have the shots. I am allergic to all meds and heard this histoglobulin is used to helppeople not react to drugs

  28. thelowhistaminechef Avatar

    So far we’re getting a number of people reporting improvements in just a week. Could be placebo, but either way…

  29. thelowhistaminechef Avatar

    Please do keep us updated and thanks for inspiring this exploration!

  30. thelowhistaminechef Avatar

    Will find out more in my interview with her tomorrow.

  31. Lyns Avatar
    Lyns

    Got all excited then, but I am hyperallergic to all pulses 🙁

  32. jane Avatar
    jane

    Hi Tony, I am like you were thin and constant headaches amongst other symptoms and am unable to take the treatment. I am desperate to be helped. If drs are against this treatment how did you manage to get the Burghwood clinic to give you the shots. Just wondered as I definitely would like to pursue this. Any advice greatly appreciated.

  33. leighlennox Avatar
    leighlennox

    That’s awesome! And a happy coincidence that I just purchased pea shoots for the first time at our farmers market yesterday! 🙂

  34. Wendy Avatar
    Wendy

    If pea seedlings have the property of boosting DAO, wouldn’t it be likely that other legume sprouts would as well? Has that been tested? Mung bean sprouts, for examples, are incredibly easy to come by, and if they do the same thing, would be a great source for people with HI

  35. thelowhistaminechef Avatar

    Hiya Wendy, indeed, she says in the first post that legumes in general work.

  36. karen Avatar
    karen

    Yasmina, I was wondering if you can freeze the pea sprouts? Will they keep there DAO?

  37. thelowhistaminechef Avatar

    I wouldn’t think so, but I will ask Dr Joneja the next time we speak!

  38. trine Avatar
    trine

    i bought 500g organic peas and put them into a jar with water for about three days and than i planted them on my balcony… now, after two weeks i have a LOT of sprouts! they sprout really fast. and they are delicious in my green smoothies 🙂 thanks for all the input!!!

  39. trine Avatar
    trine

    i bought 500g organic peas and put them into a jar with water for about three days and than i planted them on my balcony… now, after two weeks i have a LOT of sprouts! they sprout really fast. and they are delicious in my green smoothies 🙂 thanks for all the input!!!

  40. Bethany O'Toole Avatar
    Bethany O’Toole

    My DAO production is “worryingly low” according to the specialist..which explains my histamine intolerance entirely! I am VERY keen to start sprouting these to see if they help as I am being pushed more and more to take meds!

    *runs to buy some pea shoots*

  41. Bethany O'Toole Avatar
    Bethany O’Toole

    My DAO production is “worryingly low” according to the specialist..which explains my histamine intolerance entirely! I am VERY keen to start sprouting these to see if they help as I am being pushed more and more to take meds!

    *runs to buy some pea shoots*

  42. thelowhistaminechef Avatar

    Yay!! So happy to hear it 🙂

  43. thelowhistaminechef Avatar

    I’m so sorry to hear it love 🙁 I was allergic to soy and now am not. There’s always hope it’ll go away at some point. Obviously don’t eat what you’re allergic to, but know there’s hope xo

  44. Kamilla Avatar
    Kamilla

    You once wrote which DAO supplement product you think is the best. I cant find the post about it. Could you link or tell me which one?

  45. Janelle Pavey Avatar
    Janelle Pavey

    Have you reached out to Dr. Ben Lynch to formulate a vegetarian DAO Supplement?

  46. Janelle Pavey Avatar
    Janelle Pavey

    Have you reached out to Dr. Ben Lynch to formulate a vegetarian DAO Supplement?

  47. runLB Avatar
    runLB

    Very interesting post and I’d like to try the pea shoots. I found snow pea shoots at my local Whole Foods. Is that the same thing?

    What about how to prepare them? Just raw, in salad, etc. or can they be cooked in stir fry, etc.?

    Thanks!

  48. runLB Avatar
    runLB

    Very interesting post and I’d like to try the pea shoots. I found snow pea shoots at my local Whole Foods. Is that the same thing?

    What about how to prepare them? Just raw, in salad, etc. or can they be cooked in stir fry, etc.?

    Thanks!

  49. Jen Avatar
    Jen

    I was so excited to find this until I read pea and legume, which my son is highly allergic to. Any alternatives?

  50. Jen Avatar
    Jen

    I was so excited to find this until I read pea and legume, which my son is highly allergic to. Any alternatives?

  51. Christy Anderson Avatar
    Christy Anderson

    I heard that people that have high levels of copper have histamine related issues. Any word on that?

  52. Christy Anderson Avatar
    Christy Anderson

    I heard that people that have high levels of copper have histamine related issues. Any word on that?

  53. Christy Anderson Avatar
    Christy Anderson

    So how is copper regulated?

    By metallothionein (MT) (a family of cysteine-rich proteins and a wonderful antioxidant in its own right) in the GI tract where most MT exists. If a person has an excess of copper in the GI tract, more MT is automatically expressed, which then binds to copper and prevents the amount of copper that can make it into the liver and bloodstream.

    That’s the primary way copper is regulated or to put it another way, copper elevation is prevented.

    When a person has chronic, elevated copper, it means there is a genetic weakness to MT function. When copper gets into the bloodstream, it gets there by binding to proteins such as albumen as it leaves the intestinal membrane, then goes into the liver where most of the copper becomes bound to ceruloplasmin (copper-binding protein that acts like a chaperone carrying copper throughout the body and delivering it where it’s needed).

    What’s also interesting is ceruloplasmin’s ability to destroy histamines (along with the copper containing enzyme histaminase).

    In a normal, healthy individual, copper is regulated throughout the bloodstream and bound to ceruloplasmin. If you wind up with too much copper in the liver, the excess is supposed to bind with ceruloplasmin and MT, and go out through the bile duct.

    A small percentage of free copper is normal, but if a person has a much higher level – higher than 30% – this is a definite indicator of high oxidative stress.

  54. Christy Anderson Avatar
    Christy Anderson

    So how is copper regulated?

    By metallothionein (MT) (a family of cysteine-rich proteins and a wonderful antioxidant in its own right) in the GI tract where most MT exists. If a person has an excess of copper in the GI tract, more MT is automatically expressed, which then binds to copper and prevents the amount of copper that can make it into the liver and bloodstream.

    That’s the primary way copper is regulated or to put it another way, copper elevation is prevented.

    When a person has chronic, elevated copper, it means there is a genetic weakness to MT function. When copper gets into the bloodstream, it gets there by binding to proteins such as albumen as it leaves the intestinal membrane, then goes into the liver where most of the copper becomes bound to ceruloplasmin (copper-binding protein that acts like a chaperone carrying copper throughout the body and delivering it where it’s needed).

    What’s also interesting is ceruloplasmin’s ability to destroy histamines (along with the copper containing enzyme histaminase).

    In a normal, healthy individual, copper is regulated throughout the bloodstream and bound to ceruloplasmin. If you wind up with too much copper in the liver, the excess is supposed to bind with ceruloplasmin and MT, and go out through the bile duct.

    A small percentage of free copper is normal, but if a person has a much higher level – higher than 30% – this is a definite indicator of high oxidative stress.

  55. julias Avatar
    julias

    yep, legumes also can be an issue with Methylation problems…wonder if there is a way around it. Sprouting does change the whole picture

  56. julias Avatar
    julias

    yep, legumes also can be an issue with Methylation problems…wonder if there is a way around it. Sprouting does change the whole picture

  57. julias Avatar
    julias

    Jen, the fact these are sprouted could change that…many people allergic to wheat and other grains can eat if sprouted…Im interested to find out

  58. julias Avatar
    julias

    Jen, the fact these are sprouted could change that…many people allergic to wheat and other grains can eat if sprouted…Im interested to find out

  59. Sedary Avatar
    Sedary

    Sprouted wheat contains a chemical which made it even more troublesome for me. (I can’t remember the name of it and no time to remind myself via research.)

  60. Sedary Avatar
    Sedary

    Sprouted wheat contains a chemical which made it even more troublesome for me. (I can’t remember the name of it and no time to remind myself via research.)

  61. Jj Avatar
    Jj

    Did anyone have any success with this?

  62. leslie alan Avatar
    leslie alan

    Where did everyone land with this experiment? I just read this post today and bought some mung beans. Hoping for the best!

  63. Ruth Avatar
    Ruth

    Well, this is great!
    I´ve just find this…

    I´d like to try but I also have fructose malabsorption. I have seen contradictory data online about pea sprouts fructose or sugar contents.. So, do you have any reliable information about the fructose content in the pea shoots?
    Thanks!!

  64. Chef Mary Avatar
    Chef Mary

    I have a severe allergy to pea protein, so unfortunately I can’t try this out. I have a non allergic sensitivity to corn, so I can’t take the commercial dao supplements. Unfortunately, corn aggravates my migraines. Have any other methods been found to improve dao levels? I’m only recently realizing that histamine intolerance is a major problem for me. I’ve been following a low tyramine diet, and it has helped, but it is becoming clear that I must also avoid histamine rich foods. Thank you for any advice you can offer!

  65. Silvia Squirre Avatar
    Silvia Squirre

    have you ever tried fixing your gut flora? Some spore based probiotics like MegaSporeBiotic may work.

  66. Silvia Squirre Avatar
    Silvia Squirre

    have you ever tried fixing your gut flora? Some spore based probiotics like MegaSporeBiotic may work.

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Welcome!

Yasmina was an award-winning broadcast journalist with a decade of experience covering war zones for CNN and the BBC. She devoted her journalism skills to researching and writing about histamine. Click here to learn about her. Each post is carefully and fully referenced with the latest scientific research. Not sure where to start? Here’s a four week meal plan and overall Histamine Reset.


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